cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

Ngo-1902, u-Hermann Emil Fischer wahlukanisa i-hydroxyproline ku-gelatin ene-hydrolyzed.Ngo-1905, u-Hermann Leuchs wahlanganisa ingxube ye-racemic ye-4-hydroxyproline.

I-Hydroxyproline ihlukile ku-proline uma kukhona amaqembu e-hydroxyl (OH) exhunywe kuma-athomu e-gamma carbon.

IHydroxyproline ikhiqizwa yi-hydroxylation ye-amino acid proline nge-prolyl hydroxylase ngemva kokuhlanganiswa kwamaprotheni.Ukusabela okwenziwe nge-enzyme kwenzeka ngaphakathi kwe-endoplasmic reticulum lumen.Nakuba ingafakwanga ngokuqondile kumaprotheni, i-hydroxyproline yenza cishe amaphesenti angu-4 awo wonke ama-amino acid atholakala ezicutshini zezilwane, ngaphezu kwamanye ama-amino acid ayisikhombisa ahlanganisiwe.

i-collagen
IHydroxyproline iyisakhi esiyinhloko se-collagen, ehlanganisa cishe u-13.5% we-collagen encelisayo.I-Hydroxyproline ne-proline zidlala indima ebalulekile ekuzinzeni kwe-collagen.Bavumela ama-collagen spirals ukuthi asonte ngokucijile.Ku-collagen ejwayelekile i-XAa-Yaa-Gly triplet (lapho i-Xaa ne-Yaa kukhona noma iyiphi i-amino acid), i-proline ehlezi endaweni ye-Yaa i-hydroxylated ukuze ikhiqize ukulandelana kwe-XAa-hyp-Gly.Lokhu kuguqulwa kwezinsalela ze-proline kwandisa ukuzinza kwe-collagen triple helix.Ekuqaleni kwakuhlongozwe ukuthi ukuzinza kwakungenxa yokwakhiwa kwenethiwekhi yamabhondi e-hydrogen phakathi kweqembu le-prolyl hydroxyl kanye neqembu le-backbone carbonyl.Kuye kwaboniswa kamuva ukuthi ukwanda kozinzo ikakhulukazi kungenxa yemiphumela ye-stereoelectronic, kanye nokufakwa kwe-hydration kwezinsalela ze-hydroxyproline kunikeza ukuzinza okuncane noma okungenakho okwengeziwe.