CAS 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

Xyoo 1902, Hermann Emil Fischer cais hydroxyproline los ntawm hydrolyzed gelatin.Nyob rau hauv 1905, Hermann Leuchs tau tsim ib qho kev sib xyaw ntawm 4-hydroxyproline.

Hydroxyproline txawv ntawm proline nyob rau hauv lub xub ntiag ntawm hydroxyl pawg (OH) txuas rau gamma carbon atoms.

Hydroxyproline yog tsim los ntawm hydroxylation ntawm amino acid proline los ntawm prolyl hydroxylase tom qab cov protein synthesis.Enzyme-catalyzed cov tshuaj tiv thaiv tshwm sim hauv endoplasmic reticulum lumen.Txawm hais tias nws tsis yog koom ua ke ncaj qha rau hauv cov protein, hydroxyproline ua txog li 4 feem pua ​​​​ntawm tag nrho cov amino acids pom hauv cov ntaub so ntswg tsiaj, ntau dua li xya cov amino acids suav nrog.

collagen
Hydroxyproline yog qhov tseem ceeb ntawm collagen, suav txog li 13.5% ntawm mammalian collagen.Hydroxyproline thiab proline ua lub luag haujlwm tseem ceeb hauv collagen stability.Lawv tso cai rau collagen spirals mus twist sharply.Nyob rau hauv ib txwm collagen XAa-Yaa-Gly triplet (qhov twg Xaa thiab Yaa yog ib qho amino acid), cov proline tuav lub Yaa txoj hauj lwm yog hydroxylated los tsim XAa-hyp-Gly ib ntus.Qhov kev hloov kho ntawm proline residues nce kev ruaj ntseg ntawm collagen triple helix.Nws yog thawj zaug tau hais tias kev ruaj ntseg yog vim yog tsim los ntawm kev sib txuas ntawm hydrogen bonds ntawm pawg prolyl hydroxyl thiab cov pob txha carbonyl pawg.Tom qab ntawd nws tau pom tias qhov nce hauv kev ruaj ntseg yog feem ntau los ntawm cov teebmeem stereoelectronic, nrog rau cov dej ntawm hydroxyproline residues muab me ntsis lossis tsis muaj kev ruaj ntseg ntxiv.