cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

A cikin 1902, Hermann Emil Fischer ya ware hydroxyproline daga gelatin hydrolyzed.A cikin 1905, Hermann Leuchs ya haɗa wani cakuda tseren 4-hydroxyproline.

Hydroxyproline ya bambanta da proline a gaban ƙungiyoyin hydroxyl (OH) waɗanda aka haɗe zuwa gamma carbon atom.

Ana samar da Hydroxyproline ta hanyar hydroxylation na proline na amino acid ta hanyar prolyl hydroxylase bayan haɗin furotin.Abubuwan da ke haifar da haɓakar enzyme suna faruwa a cikin lumen endoplasmic reticulum lumen.Ko da yake ba a haɗa shi kai tsaye cikin sunadaran ba, hydroxyproline shine kusan kashi 4 cikin ɗari na duk amino acid da ake samu a cikin nama na dabba, fiye da sauran amino acid bakwai da aka haɗa.

collagen
Hydroxyproline shine babban bangaren collagen, yana lissafin kusan kashi 13.5% na collagen na mammalian.Hydroxyproline da proline suna taka muhimmiyar rawa a cikin kwanciyar hankali na collagen.Suna ba da damar spirals collagen su karkata sosai.A cikin nau'in collagen XAa-Yaa-Gly sau uku (inda Xaa da Yaa suke kowane amino acid), proline da ke mamaye matsayin Yaa yana hydroxylated don samar da jerin XAa-hyp-Gly.Wannan gyare-gyare na ragowar proline yana ƙaruwa da kwanciyar hankali na helix na collagen sau uku.An fara ba da shawarar cewa kwanciyar hankali ya kasance saboda samuwar hanyar sadarwa na haɗin gwiwar hydrogen tsakanin ƙungiyar prolyl hydroxyl da ƙungiyar carbonyl na baya.Daga baya an nuna cewa haɓakar kwanciyar hankali shine yafi ta hanyar tasirin sitiriyo, tare da hydration na ragowar hydroxyproline yana ba da ƙarancin kwanciyar hankali ko babu ƙarin kwanciyar hankali.