cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

Muna 1902, Hermann Emil Fischer akaparadzanisa hydroxyproline kubva kuhydrolyzed gelatin.Muna 1905, Hermann Leuchs akagadzira musanganiswa weracemic we4-hydroxyproline.

Hydroxyproline inosiyana kubva kune proline pamberi pemapoka ehydroxyl (OH) akanamatira gamma kabhoni maatomu.

Hydroxyproline inogadzirwa nehydroxylation yeamino acid proline neprolyl hydroxylase mushure meprotein synthesis.Enzyme-catalyzed reactions inoitika mukati me endoplasmic reticulum lumen.Kunyange zvazvo isina kuiswa zvakananga mumapuroteni, hydroxyproline inoumba inenge 4 muzana yemamino acids anowanikwa munyama yemhuka, kupfuura mamwe manomwe manomwe amino acids akabatanidzwa.

collagen
Hydroxyproline ndiyo chikamu chikuru che collagen, inoverengera inosvika 13.5% yemammalian collagen.Hydroxyproline uye proline inoita basa rakakosha mukugadzikana kwecollagen.Vanobvumira collagen spirals kumonyoroka zvakanyanya.Mune yakajairwa collagen XAa-Yaa-Gly katatu (apo Xaa neYaa chero amino acid), iyo proline inogara iyo Yaa chinzvimbo ndeye hydroxylated kuburitsa iyo XAa-hyp-Gly kutevedzana.Uku kuchinjwa kweproline residues kunowedzera kugadzikana kwe collagen katatu helix.Pakutanga yaifungidzirwa kuti kugadzikana kwakakonzerwa nekuumbwa kwetiweki yezvisungo zvehydrogen pakati peprolyl hydroxyl boka uye musana wecarbonyl boka.Izvo zvave zvichiratidzwa kuti kuwedzera kwekugadzikana kunonyanya kuburikidza ne stereoelectronic mhedzisiro, ine hydration ye hydroxyproline residues inopa kushoma kana kusazowedzera kugadzikana.