cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

Na 1902, Hermann Emil Fischer kewapụrụ hydroxyproline na gelatin hydrolyzed.Na 1905, Hermann Leuchs weputara ngwakọta agbụrụ nke 4-hydroxyproline.

Hydroxyproline dị iche na proline na ọnụnọ nke otu hydroxyl (OH) jikọtara na gamma carbon atom.

A na-emepụta Hydroxyproline site na hydroxylation nke amino acid proline site na prolyl hydroxylase mgbe njikọ protein gasịrị.Mmeghachi omume nke enzyme-catalyzed na-eme n'ime endoplasmic reticulum lumen.Ọ bụ ezie na etinyeghị ya ozugbo na protein, hydroxyproline na-eme ihe dị ka pasent 4 nke amino acid niile a na-ahụ n'anụmanụ, karịa amino acid asaa ndị ọzọ agbakwunyere.

collagen
Hydroxyproline bụ isi akụrụngwa nke collagen, na-aza ihe dị ka 13.5% nke mammalian collagen.Hydroxyproline na proline na-arụ ọrụ dị mkpa na nkwụsi ike nke collagen.Ha na-ekwe ka spirals collagen na-agbagọ nke ọma.Na ụdị collagen XAa-Yaa-Gly triplet (ebe Xaa na Yaa bụ amino acid ọ bụla), proline na-ebi n'ọnọdụ Yaa bụ hydroxylated iji mepụta usoro XAa-hyp-Gly.Mgbanwe a nke ihe fọdụrụ proline na-eme ka nkwụsi ike nke helix collagen triple.A tụrụ ya na mbụ na nkwụsi ike bụ n'ihi nhazi netwọk nke njikọ hydrogen n'etiti otu prolyl hydroxyl na ọkpụkpụ azụ carbonyl.E mechara gosi na mmụba nke nkwụsi ike bụ tumadi site na mmetụta stereoelectronic, na hydration nke residues hydroxyproline na-enye ntakịrị ma ọ bụ enweghị nkwụsi ike ọzọ.