cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hīroita gelatin

I te tau 1902, ka wehea e Hermann Emil Fischer te hydroxyproline mai i te gelatin kua whakamarohia.I te tau 1905, ka whakahiatotia e Hermann Leuchs he ranunga raihi o te 4-hydroxyproline.

He rereke te Hydroxyproline i te proline i te aroaro o nga roopu hydroxyl (OH) e piri ana ki nga ngota waro gamma.

Ko te Hydroxyproline ka hangaia ma te hydroxylation o te waikawa amino proline na te prolyl hydroxylase i muri i te whakahiato pūmua.Ka puta nga tauhohenga whakangao i roto i te lumen reticulum endoplasmic.Ahakoa kaore i whakauruhia ki roto i nga pūmua, ko te hydroxyproline te 4 paiheneti o nga waikawa amino katoa e kitea ana i roto i te kiko kararehe, nui atu i era atu waikawa amino e whitu kua whakauruhia.

collagen
Ko te Hydroxyproline te waahanga matua o te collagen, e tata ana ki te 13.5% o te collagen mammalian.Ko te Hydroxyproline me te proline he mahi nui ki te pumau o te collagen.Ka tukuna e ratou nga torino collagen ki te huri koi.I roto i te collagen angamaheni XAa-Yaa-Gly triplet (kei hea Xaa me Yaa he waikawa amino), ko te proline e noho ana i te turanga Yaa ka hydroxylated hei whakaputa i te raupapa XAa-hyp-Gly.Ko tenei whakarereketanga o nga toenga proline ka piki ake te pumau o te collagen triple helix.I whakaarohia i te tuatahi ko te pumau na te hanganga o te kupenga o nga here hauwai i waenga i te roopu hydroxyl prolyl me te roopu carbonyl backbone.I muri mai kua whakaatuhia ko te pikinga o te pumau na te nuinga o nga paanga stereoelectronic, me te whakamakuku o nga toenga hydroxyproline he iti noa, kaore ranei he taapiri.