cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

I ka makahiki 1902, ua hoʻokaʻawale ʻo Hermann Emil Fischer i ka hydroxyproline mai ka gelatin hydrolyzed.I ka makahiki 1905, ua hana ʻo Hermann Leuchs i kahi hui racemic o 4-hydroxyproline.

ʻOkoʻa ka Hydroxyproline mai ka proline i mua o nā pūʻulu hydroxyl (OH) i hoʻopili ʻia i nā ʻātoma kalapona gamma.

Hana ʻia ka Hydroxyproline e ka hydroxylation o ka amino acid proline e prolyl hydroxylase ma hope o ka synthesis protein.Hana ʻia nā hopena enzyme-catalyzed i loko o ka endoplasmic reticulum lumen.ʻOiai ʻaʻole i hoʻokomo pono ʻia i loko o nā protein, ʻo ka hydroxyproline ka mea e hana ai ma kahi o 4 pakeneka o nā amino acids a pau i loaʻa i loko o ka ʻiʻo holoholona, ​​ʻoi aku ma mua o nā ʻāpana amino ʻehiku i hoʻohui ʻia.

kolagena
ʻO Hydroxyproline ka mea nui o ka collagen, e helu ana ma kahi o 13.5% o ka collagen mammalian.ʻO ka hydroxyproline a me ka proline ka mea nui i ka paʻa ʻana o ka collagen.Hāʻawi lākou i nā spiral collagen e wili ikaika.I ka typical collagen XAa-Yaa-Gly triplet (kahi Xaa a me Yaa kekahi amino acid), ka proline e noho ana i ka Yaa kulana ua hydroxylated e hana i ka XAa-hyp-Gly sequence.ʻO kēia hoʻololi o nā koena proline e hoʻonui i ka paʻa o ka collagen triple helix.Ua manaʻo mua ʻia ʻo ka paʻa ʻana ma muli o ka hoʻokumu ʻana o kahi pūnaewele o nā paʻa hydrogen ma waena o ka pūʻulu hydroxyl prolyl a me ka hui carbonyl iwi kuamoʻo.Ma hope mai ua hōʻike ʻia ka piʻi ʻana o ka paʻa ma o nā hopena stereoelectronic, me ka hydration o nā koena hydroxyproline e hāʻawi liʻiliʻi a ʻaʻohe paʻa hou.