cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

Mu 1902, Hermann Emil Fischer anapatula hydroxyproline kuchokera ku gelatin ya hydrolyzed.Mu 1905, Hermann Leuchs adapanga chisakanizo cha 4-hydroxyproline.

Hydroxyproline imasiyana ndi proline pamaso pa magulu a hydroxyl (OH) omwe amamangiriridwa ku maatomu a kaboni a gamma.

Hydroxyproline imapangidwa ndi hydroxylation ya amino acid proline ndi prolyl hydroxylase pambuyo popanga mapuloteni.Zochita za enzyme zimachitika mkati mwa endoplasmic reticulum lumen.Ngakhale kuti simaphatikizidwe mwachindunji m’mapuloteni, hydroxyproline imapanga pafupifupi 4 peresenti ya ma amino acid onse opezeka m’minyewa ya nyama, kuposa ma amino acid ena asanu ndi awiri ophatikizidwa.

kolajeni
Hydroxyproline ndiye chigawo chachikulu cha collagen, chomwe chimawerengera pafupifupi 13.5% ya mammalian collagen.Hydroxyproline ndi proline zimagwira ntchito yofunika kwambiri pakukhazikika kwa collagen.Amalola kuti ma collagen spirals azipotokola kwambiri.Mu collagen wamba XAa-Yaa-Gly katatu (komwe Xaa ndi Yaa ali amino acid iliyonse), proline yomwe ikukhala pa Yaa imakhala ndi hydroxylated kuti ipange mndandanda wa XAa-hyp-Gly.Kusintha kumeneku kwa zotsalira za proline kumawonjezera kukhazikika kwa collagen triple helix.Poyamba adaganiza kuti kukhazikika kudachitika chifukwa chopanga maukonde a haidrojeni pakati pa gulu la prolyl hydroxyl ndi gulu la backbone carbonyl.Pambuyo pake zasonyezedwa kuti kuwonjezereka kwa kukhazikika kumakhala makamaka kudzera mu zotsatira za stereoelectronic, ndi hydration ya zotsalira za hydroxyproline zomwe zimapereka kukhazikika pang'ono kapena osawonjezera.