cas 51-35-4 L-Hydroxyproline Amino aside glycoprotein Hydrolyzed gelatin

Mu 1902, Hermann Emil Fischer yatandukanije hydroxyproline na gelatine hydrolyzed.Mu 1905, Hermann Leuchs yashushanyije ivanguramoko rivanze na 4-hydroxyproline.

Hydroxyproline itandukanye na proline imbere ya hydroxyl (OH) ifatanye na atome ya karubone.

Hydroxyproline ikorwa na hydroxylation ya aside amine acide na prolyl hydroxylase nyuma ya synthesis.Enzyme-catalysed reaction ibaho muri endoplasmic reticulum lumen.Nubwo itinjijwe muri poroteyine mu buryo butaziguye, hydroxyproline igizwe na 4 ku ijana bya aside amine yose iboneka mu nyama z’inyamaswa, kurusha izindi aside irindwi irindwi yashizwemo

kolagen
Hydroxyproline nikintu nyamukuru kigizwe na kolagen, bingana na 13.5% byinyamabere.Hydroxyproline na proline bigira uruhare runini mugutuza kwa kolagen.Bemerera kolagen spiral izunguruka cyane.Mubisanzwe bya kolagen XAa-Yaa-Gly inyabutatu (aho Xaa na Yaa ari aside amine iyo ari yo yose), protine ifata umwanya wa Yaa iba hydroxylated kugirango ikore XAa-hyp-Gly ikurikiranye.Ihinduka ryibisigazwa bya proline byongera ituze rya kolagen triple helix.Byabanje gusabwa ko ituze ryatewe no gushiraho urusobe rwamazi ya hydrogène hagati ya prolyl hydroxyl nitsinda rya karubone.Byagaragaye nyuma ko kwiyongera kwumutekano guterwa ahanini ningaruka za stereoelectronic, hamwe nogutwara ibisigazwa bya hydroxyproline bitanga bike cyangwa ntamahoro bihamye.