cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

Ka 1902, Hermann Emil Fischer o ile a arola hydroxyproline ho tloha ho gelatin ea hydrolyzed.Ka 1905, Hermann Leuchs o ile a etsa motsoako oa racemic oa 4-hydroxyproline.

Hydroxyproline e fapane le proline ka boteng ba lihlopha tsa hydroxyl (OH) tse khomaretsoeng ho liathomo tsa khabone ea gamma.

Hydroxyproline e hlahisoa ke hydroxylation ea amino acid proline ka prolyl hydroxylase ka mor'a protheine synthesis.Karabelo ea enzyme e etsahala ka har'a lumen ea endoplasmic reticulum.Le hoja e sa kenyelletsoa ka ho toba liprotheine, hydroxyproline e etsa hoo e ka bang karolo ea 4 lekholong ea li-amino acid tse fumanoang liseleng tsa liphoofolo, ho feta tse ling tse supileng tsa amino acid tse kenyelletsoeng.

collagen
Hydroxyproline ke karolo ea mantlha ea collagen, e nkang karolo ea 13.5% ea collagen ea mammalian.Hydroxyproline le proline li bapala karolo ea bohlokoa botsitsong ba collagen.Li lumella li-spirals tsa collagen ho sotheha haholo.Ka collagen e tloaelehileng ea XAa-Yaa-Gly triplet (moo Xaa le Yaa e leng amino acid leha e le efe), proline e lutseng sebakeng sa Yaa ke hydroxylated ho hlahisa tatellano ea XAa-hyp-Gly.Phetoho ena ea masala a proline e eketsa botsitso ba collagen triple helix.Qalong ho ile ha etsoa tlhahiso ea hore botsitso bo bakoa ke ho thehoa ha marang-rang a li-hydrogen bond pakeng tsa sehlopha sa prolyl hydroxyl le sehlopha sa mokokotlo oa carbonyl.Ka mor'a moo ho bonts'itsoe hore keketseho ea botsitso e bakoa haholo ke liphello tsa stereoelectronic, 'me hydration ea masala a hydroxyproline e fana ka botsitso bo fokolang kapa bo se nang letho.