cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

Ni ọdun 1902, Hermann Emil Fischer ya sọtọ hydroxyproline lati gelatin hydrolyzed.Ni ọdun 1905, Hermann Leuchs ṣe akojọpọ idapọ-ije ti 4-hydroxyproline.

Hydroxyproline yato si proline ni iwaju awọn ẹgbẹ hydroxyl (OH) ti a so mọ awọn ọta carbon gamma.

Hydroxyproline jẹ iṣelọpọ nipasẹ hydroxylation ti proline amino acid nipasẹ prolyl hydroxylase lẹhin iṣelọpọ amuaradagba.Awọn aati enzyme-catalyzed waye laarin endoplasmic reticulum lumen.Botilẹjẹpe a ko dapọ mọ taara sinu awọn ọlọjẹ, hydroxyproline jẹ to bii 4 ida ọgọrun ti gbogbo awọn amino acids ti a rii ninu ẹran ara ẹranko, diẹ sii ju awọn amino acid meje miiran ti o dapọ.

akojọpọ
Hydroxyproline jẹ paati akọkọ ti collagen, ṣiṣe iṣiro fun iwọn 13.5% ti collagen mammalian.Hydroxyproline ati proline ṣe ipa pataki ninu iduroṣinṣin collagen.Wọn gba awọn spirals collagen lati yi ni didan.Ni aṣoju collagen XAa-Yaa-Gly triplet (nibiti Xaa ati Yaa jẹ eyikeyi amino acid), proline ti o wa ni ipo Yaa jẹ hydroxylated lati ṣe agbekalẹ XAa-hyp-Gly.Yi iyipada ti awọn iṣẹku proline ṣe alekun iduroṣinṣin ti helix meteta collagen.Ni akọkọ ti dabaa pe iduroṣinṣin jẹ nitori idasile ti nẹtiwọọki kan ti awọn asopọ hydrogen laarin ẹgbẹ prolyl hydroxyl ati ẹgbẹ carbonyl ẹhin.O ti ṣe afihan nigbamii pe ilosoke ninu iduroṣinṣin jẹ nipataki nipasẹ awọn ipa sitẹrioelectronic, pẹlu hydration ti awọn iṣẹku hydroxyproline ti n pese iduroṣinṣin diẹ tabi ko si afikun.