cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein Hydrolyzed gelatin

Ngowe-1902, uHermann Emil Fischer wahlukanisa i-hydroxyproline kwi-gelatin ene-hydrolyzed.Ngo-1905, uHermann Leuchs wenza umxube we-racemic we-4-hydroxyproline.

IHydroxyproline iyahluka kwiproline xa kukho amaqela e-hydroxyl (OH) edityaniswe kwi-athom ye-gamma carbon.

I-Hydroxyproline iveliswa yi-hydroxylation ye-amino acid proline nge-prolyl hydroxylase emva kwe-protein synthesis.Iintshukumo ze-Enzyme-catalyzed zenzeka ngaphakathi kwe-endoplasmic reticulum lumen.Nangona ingabandakanywanga ngokuthe ngqo kwiiprotheni, i-hydroxyproline yenza malunga ne-4 ekhulwini yazo zonke ii-amino acids ezifumaneka kwizicubu zezilwanyana, ngaphezu kwezinye ezisixhenxe ze-amino acids ezidityanisiweyo.

icollagen
IHydroxyproline yeyona nxalenye iphambili yecollagen, ibalwa malunga ne-13.5% ye-collagen eyanyisayo.I-Hydroxyproline kunye neproline idlala indima ebalulekileyo ekuzinzeni kwe-collagen.Bavumela i-collagen spirals ukuba ijike ngokukhawuleza.Kwi-collagen eqhelekileyo i-XAa-Yaa-Gly triplet (apho i-Xaa kunye ne-Yaa nayiphi na i-amino acid), i-proline ehlala kwindawo ye-Yaa i-hydroxylated ukuvelisa ukulandelelana kwe-XAa-hyp-Gly.Oku kuguqulwa kweentsalela zeproline kwandisa ukuzinza kwe-collagen triple helix.Ekuqaleni kwakucetywayo ukuba ukuzinza kwakungenxa yokuqulunqwa kwenethiwekhi yeebhondi ze-hydrogen phakathi kweqela le-prolyl hydroxyl kunye neqela le-backbone carbonyl.Kuye kwaboniswa emva koko ukuba ukonyuka kozinzo kubangelwa ikakhulu ziimpembelelo ze-stereoelectronic, kunye ne-hydration yeentsalela ze-hydroxyproline ezibonelela kancinci okanye akukho uzinzo olongezelelweyo.