cas 51-35-4 L-Hydroxyproline Amino acid glycoprotein hydrolyzata gelatina

Anno 1902, Hermann Emil Fischer hydroxyprolinum ab hydrolyzata gelatina segregavit.Anno 1905, Hermann Leuchs mixturam racemicam 4-hydroxyprolineum perstringit.

Hydroxyprolinum differt a proline coram coetibus hydroxyli (OH) atomis carbonis gamma affixis.

Hydroxyprolineum per hydroxylationem amino acid proline per prolyl hydroxylasim post synthesim interdum producitur.reactiones enzyme-catalytici occurrunt intra reticulum lumen endoplasmicum.Etsi non directe in servo incorporatum est, hydroxyprolinum facit circiter 4 centesimas omnium amino acidarum in textura animali inventarum, plus quam septem amino acida incorporata.

collagen
Hydroxyprolinum principale est collagenium, ratio circiter 13.5% collageni mammalium.Hydroxyprolinea et prolinea in collageni stabilitate partes clavis agunt.Collagen spiras permittunt acriter torquere.In collagen typico XAa-Yaa-Gly triplum (ubi Xaa et Yaa sunt amino acido) proline occupans Yaa situm hydroxylated ad seriem XAa-Hyp-Gly producendam.Haec modificatio reliquiarum prolinorum auget stabilitatem collageni helix tripli.Propositum est stabilitatem debitam formationi vinculorum hydrogenii retis inter coetus prolyl hydroxyli et globi carbonylis spinae.Ostensum deinde est incrementum stabilitatis esse maxime per effectus stereoelectronic, cum residua hydroxyprolinea parum vel nulla stabilitate addita praebens.