CAS: 77472-71-0 2-Oxo-4-Phenyl-1-Pyrrolidineacetic Acid Hydrazide Phenylpiracetam hydrazine

N-formyl itọsẹ 4 ni a gba nipasẹ reflux ti 2 ni formic acid fun awọn wakati 5 ni ikore giga.Acetic acid N'-[2- (7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl] -hydrazide (5) ni a gba nipasẹ reflux acetylation ti 2 ni acetic acid ni ikore to dara.Apapo 6 tun gba nipasẹ refluxing 2 pẹlu 3- (2-bromoacetyl) -4-hydroxy-2 H-chromen-2-ọkan ninu ethanol.Apapo 2 ṣe atunṣe pẹlu phenyl isothiocyanate ni ethanol ni iwọn otutu yara lati gba 4-phenyl-1- (7-hydroxy-2-oxo-2 H-chromen-4-acetyl -) - thiosemicarbazide (7).
3-{2-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]hydrazono}butanoate (8) ethyl ester (8), 3-{2-[2- 7-hydroxy-2-oxo-2 H-Chromen-4-yl) -acetyl] Hydrazono} Butanoate (8), Awọn ikore wà 48% (Aṣayan 2).Ilana ti awọn agbo ogun 4-8 jẹ ipinnu nipasẹ data itupalẹ wọn ati IR ati 1 H-NMR spectra wọn.Gbigba infurarẹẹdi nitori awọn iṣẹ NH, OH ati C=O han ni 3450-3000 ati 1728-1610cm-1, lẹsẹsẹ.Awọn ẹgbẹ gbigba ti o ni nkan ṣe pẹlu wiwa awọn ẹgbẹ iṣẹ ṣiṣe miiran wa ni agbegbe ti a nireti.1 H-NMR julọ.Oniranran ti agbo naa ṣe afihan tente oke kan ni agbegbe 8.03-10.58ppm ti o baamu si awọn protons NH ati OH.Apapo 4-8