CAS: 77472-71-0 2-Oxo-4-Phenyl-1-Pyrrolidineacetic Acid Hydrazide Phenylpiracetam hydrazine

Loaʻa ka N-formyl derivative 4 ma ka reflux o 2 i ka waika formic no 5 mau hola ma kahi hua kiʻekiʻe.Acetic acid N'-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]-hydrazide (5) i loaʻa ma ka reflux acetylation o 2 i ka acetic acid ma kahi hua maikaʻi.Loaʻa pū ʻia ka hui 6 ma ka refluxing 2 me 3-(2-bromoacetyl) -4-hydroxy-2 H-chromen-2-one i loko o ka ethanol.Hoʻopili ka hui 2 me ka phenyl isothiocyanate i loko o ka ethanol ma ka wela lumi e loaʻa ai ka 4-phenyl-1-(7-hydroxy-2-oxo-2 H-chromen-4-acetyl -)-thiosemicarbazide (7).
3-{2-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]hydrazono}butanoate (8) ethyl ester (8), 3-{2-[2-( 7-hydroxy-2-oxo-2 H-Chromen-4-yl)-acetyl] Hydrazono} Butanoate (8), He 48% ka hua (koho 2).Hoʻoholo ʻia ke ʻano o nā pūhui 4-8 e kā lākou ʻikepili analytical a me kā lākou IR a me 1 H-NMR spectra.Hōʻike ʻia ka absorption infrared ma muli o nā hana NH, OH a me C=O ma 3450-3000 a me 1728-1610cm-1.Aia nā pūʻulu absorption e pili ana i ka hiki ʻana o nā pūʻulu hana ʻē aʻe ma ka ʻāina i manaʻo ʻia.Hōʻike ka 1 H-NMR spectrum o ka pūhui i ka piko hoʻokahi ma ka ʻāpana 8.03-10.58ppm e pili ana i nā protons NH a me OH.Huina 4-8