CAS: 77472-71-0 2-Oxo-4-Phenyl-1-Pyrrolidineacetic Acid Hydrazide Phenylpiracetam hydrazine

Ko te N-formyl derivative 4 i riro mai i te reflux o te 2 i roto i te waikawa formic mo nga haora 5 i te hua nui.Acetic acid N'-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]-hydrazide (5) i riro mai i te reflux acetylation o 2 i roto i te waikawa acetic i te hua pai.Ka whiwhi ano te Puhui 6 ma te whakamaarama i te 2 ki te 3-(2-bromoacetyl) -4-hydroxy-2 H-chromen-2-one ki te waihā.Ka tauhohe te Puhui 2 ki te phenyl isothiocyanate i roto i te waihano i te pāmahana rūma kia whiwhi 4-phenyl-1-(7-hydroxy-2-oxo-2 H-chromen-4-acetyl -)-thiosemicarbazide (7).
3-{2-[2-(7-hydroxy-2-oxo-2 H-chromen-4-yl)-acetyl]hydrazono}butanoate (8) ethyl ester (8), 3-{2-[2-( 7-hydroxy-2-oxo-2 H-Chromen-4-yl)-acetyl] Hydrazono} Butanoate (8), Ko te hua ko te 48% (Kōwhiringa 2).Ko te hanganga o nga pūhui 4-8 i whakatauhia e o raatau raraunga tātari me o raatau IR me te 1 H-NMR hihinga.Ko te whakaurunga infrared na nga mahi NH, OH me C=O ka puta ki te 3450-3000 me te 1728-1610cm-1.Ko nga roopu whakauru e hono ana ki te aroaro o etahi atu roopu mahi kei roto i te rohe e tumanakohia ana.Ko te 1 H-NMR spectrum o te pūhui e whakaatu ana i te tihi kotahi i te rohe 8.03-10.58ppm e rite ana ki nga protons NH me OH.Huihuinga 4-8