Izongezo ezininzi eziqhelekileyo zokulwa nokuguga

Isihloko sokuchasana nokuguga siye sathandwa ngakumbi kwiminyaka yakutshanje, kunye nezifundo ezahlukeneyo eziphuma ngokungapheliyo.
Ngalo lonke ixesha, elinye iqela lophando lifumanisa into echasene nokuguga enokusinceda siphile iminyaka elikhulu.
Thina bantu sinomda wokuphila we-150 iminyaka, kuba i-telomeres ifinyeza kancinane rhoqo kwiminyaka emibini ukuya kwemithathu, kwaye iiseli zinokwahlula ngamaxesha angama-50, utsho uHafrick we-telomere Theory.
Kukho neengcali ezithile ezinethemba lokuthi: umntu wokuqala ukuba aphile ukuya kwiminyaka eyi-1000 ubudala, uzelwe, kwihlabathi lethu, inokuba nguwe oh.
Ngophuhliso lwebhayoloji yebhayoloji, ngenye imini sinokufumana into yomlingo eya kusinceda siphile ixesha elide.
Ke, phila usempilweni, usebenze nzima ukwenza imali, kwaye ulinde itekhnoloji evuthiwe ngenye imini, mhlawumbi, ungaphila ubomi obude.
Namhlanje, ndiza kukwazisa kwezinye zezona zixhaso zithembisayo zokulwa nokuguga ezaziwayo, kwaye ujonge ezimbalwa ozibonileyo.

1. Epitalon

I-Epitalon yi-peptide yokwenziwa yokulwa nokuguga, eveliswe kwi-amino acid chain alanine-glutamine-asparagine-glycine, ephakamisa umsebenzi we-telomerase emzimbeni ukuze uncede ukunciphisa izinga lokuguga.

Iitelomere zifana neminqwazi ekhusela iDNA.Uninzi lweechromosomes emzimbeni zineetelomeres kuzo zombini iziphelo;Umsebenzi oyintloko we-telomerase kukunceda ukugcina ubude be-telomeres emzimbeni.

Ezinye izifo zidibene ne-telomeres emfutshane, ekhokelela ekugugeni ngokukhawuleza;I-Epitalon ingasetyenziselwa ukunyanga izifo ezibangela ukuguga kwangaphambili, njenge-Bloom syndrome kunye ne-Werner syndrome.

I-Epitalon iphinda incede ukunciphisa umngcipheko wezifo ezinxulumene nokunqongophala kwe-telomerase, njengesifo sikashukela, ngenxa yokuba ukukhutshwa kwe-insulin kuthintelwe ukusilela kwe-telomerase.

I-peptide inokuba nefuthe elihle kwimpilo yentliziyo kwaye inokunceda ukukhusela isifo senhliziyo;Izazinzulu zifunda amandla ayo ekunyangeni amathumba.

2: Curcumin

I-Turmeric iyisithako sokutya esininzi saseNdiya, kwaye i-curcumin iyona nto ifundwa kakhulu esebenzayo kwi-turmeric, enezixhobo ezinamandla ezichasayo kunye ne-antioxidant.

Uphononongo lubonise ukuba i-curcumin yenza i-sirtuins (deacetylases) kunye ne-AMPK (AMP-activated protein kinase), enceda ukucotha ukuguga kweeseli kunye nokwandisa ubomi.

Ukongezelela, i-curcumin ibonakaliswe ukulwa nomonakalo weseli kwaye yandisa kakhulu ixesha lokuphila kweempukane zeziqhamo, ii-roundworms, kunye neegundane;Kwakhona kunokulibazisa ukuqala kwezifo ezinxulumene neminyaka kunye nokunciphisa iimpawu zezifo ezinxulumene neminyaka

3: i-cannabinoid

Iikhompawundi ezisebenzayo ze-cannabis, ezaziwa ngokudibeneyo njenge-cannabinoids, liqela le-terpenoid phenolic compounds, ezona zidumileyo zazo ziyi-tetrahydrocannabinol (THC) kunye ne-cannabidiol (CBD).

I-CBD inokulwa neeradicals zasimahla kwiiseli zolusu, zisebenza njenge-antioxidant kunye ne-anti-aging agent.Ihlala yongezwa kwiimveliso zokunakekelwa kwesikhumba kwaye isoloko isetyenziselwa ukukhulula ubuhlungu obungapheliyo, kunye nemiphumo emihle

4: spermidine

I-Spermidine yinxalenye yendalo yesidoda, kwaye imizimba yethu (yombini indoda nebhinqa) ivelisa kuphela malunga nesithathu sayo, kunye nezinye eziphuma ekutyeni kwethu.

Imithombo yayo yokutya ibandakanya: i-cheese endala, amakhowa, i-natto, i-pepper eluhlaza, i-wheat germ, i-cauliflower, i-broccoli, njl.

Abantu base-Asiya banamazinga aphezulu e-asidi ye-arginous ekudleni kwabo, enokuthi inxulumene nobomi babo obude.

Uphando lwe-spermidine luye lwakhula kwiminyaka yakutshanje, kwaye lufunyenwe luneziphumo ezilandelayo:

Yandisa ubomi obusempilweni;

Ukuphucula inqanaba lengqondo yabantu abadala;

Impembelelo ye-neuroprotective;

Ukunciphisa ukufa okubangelwa zizo zonke;

Uxinzelelo lwegazi oluphantsi;

Ukukhuthaza i-autophagy kunye nokulibaziseka kwe-senescence;

Yenza iinwele zikhule ngokukhawuleza kwaye iinzipho zomelele.

5: umzimba we-ketone

Esinye sezizathu eziphambili zokutya kwe-ketogenic zithandwa kukulahleka kwesisindo kunye nokucaca kwengqondo.

Xa umzimba uqala ukutshisa amanqatha omzimba, uvelisa imizimba ye-ketone, enika amandla acocekileyo kwingqondo kunye nokuphucula ukusebenza kwayo.

I-Ketones ineempawu zokuguga, kwaye uphando lufumene ukuba i-BHB (i-beta-hydroxybutyric acid) inokukhuthaza ukuhlukana kweeseli, ukukhusela ukuguga kweeseli, nokugcina imithwalo yegazi kunye nengqondo eselula.

Umzimba unokuvelisa imizimba ye-keto ngokuphepha i-carbohydrates, okanye unokuthatha izongezo ze-keto zangaphandle ukukhawulezisa inkqubo kunye nokunciphisa iintlungu zenguqu, eyaziwa ngokuba yi "keto flu."

Ukutya kwe-Ketogenic, okanye ukuthatha izongezo ze-keto zangaphandle, kunokucothisa ukuguga, ukuphucula ukusebenza kwengqondo, kunye nokunceda ukuthintela izifo ze-neurodeergenerative ezifana ne-Alzheimer's.

6: Dasatinib

Njengoko sikhula, ezinye iiseli zethu ziyayibaleka inkqubo yomzimba yokuzikhusela.Ezi seli “ziphilayo” azenzi into ebekufanele ukuba ziyenze, kodwa zisawatshisa amandla.

"Konke ukutya kwaye akukho msebenzi" iiseli, ezaziwa nangokuthi "iiseli ze-zombie", okanye iiseli ze-senescent, ziqokelela ngokuhamba kwexesha, okwenza umzimba usebenze ngokufanelekileyo.

Ukuzila ukutya, umthambo kunye nezinye iindlela zokuphila ezisempilweni zibangela i-autophagy, ecoca iiseli ze-zombie.

I-Dasatinib, iyeza le-chemotherapy elisetyenziswa kunyango lwe-leukemia, liyakwazi ukususa ngokufanelekileyo iiseli zamafutha eziguga kunye nokunciphisa ukukhuselwa kwee-cytokines ezinokuvuvukala kwizicubu ze-adipose yomzimba.

Lichiza lokuqala le-Senolytics ukufunyanwa, iyeza elisusa ngokukhetha iiseli ze-senescent ngokuphazamisa iindlela zokubonisa i-cell senescent, ikhubaze okwethutyana i-SCAPs (i-anti-apoptotic pathways).

Izinto ezinokuthi zisuse iiseli zencindi ziquka i-PCC1 evela kwi-Chinese Academy of Sciences, kunye nezinye izithako ezifana ne-quercetin.