I-CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

I-Prokanatide (i-Plecanatide) isidakamizwa esisha esithinta i-guanylate cyclase, esingashukumisa ukukhishwa kwamathumbu oketshezi lwamathumbu futhi kusheshise ukukhululeka.I-polypeptide yomlomo eyakhiwe ngama-amino acid ayi-16 aklanyelwe ukulingisa i-peptide yomuntu yamathumbu, i-uranyin.I-Pucanatide, eyaqalwa i-Callisto Pharmaceuticals futhi yadluliselwa ku-Synergy Pharmaceuticals, yagunyazwa yi-US Food and Drug Administration (FDA) ukuze zelashwe i-CIC kubantu abadala ngoJanuwari 19, 2017. I-Pucanatide iyi-analogue ye-uroguanylin, i-cyclic polypeptide Chemicalbook equkethe 16 amino acid.Isebenza njenge-guanylate cyclase receptor agonist ye-sodium excretion, ilawula i-asidi nama-ion ayisisekelo epheshaneni lamathumbu, idonsela ukuthutha koketshezi emgudwini wamathumbu, futhi ikhulise i-peristalsis yamathumbu.Indlela yokwenza i-Pucanatide nama-metabolites ayo asebenzayo abopha ama-enzyme e-GC-C futhi asebenze endaweni endaweni ye-lumen yamaseli e-epithelial amathumbu.Ukwenziwa kusebenze kwe-enzyme ye-GC-C kukhulisa ukugcwala kwe-intracellular kanye ne-extracellular cyclic guanosine phosphate (cGMP), kuyilapho ukwanda kwe-intracellular cGMP concentration kuvuselela ukukhishwa kwe-chloride ne-bicarbonate kulume lwamathumbu ngokusebenzisa i-ion channel activation ye-cystic fibrosis transmembrane regulatory. factor (CFTR), enyusa futhi isheshise ukudlula koketshezi lwamathumbu.