CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

Prokanatide (Plecanatide) mushonga mutsva unobata guanylate cyclase, unogona kukurudzira kuvharika kwematumbo emukati uye kukurumidza kuita tsvina.Polypeptide yemuromo inoumbwa ne16 amino acids yakagadzirirwa kutevedzera yemunhu gastrointestinal peptide, uranyin.Pucanatide, yakatanga kugadzirwa neCallisto Pharmaceuticals ndokuendeswa kuSynergy Pharmaceuticals, yakatenderwa neUS Food and Drug Administration (FDA) kuti irapwe CIC muvanhu vakuru musi wa19 Ndira 2017. Pucanatide inofananidzira uroguanylin, cyclic polypeptide Chemicalbook ine Chemicalbook. 16 amino acids.Inoshanda se guanylate cyclase receptor agonist ye sodium excretion, inogadzirisa asidhi uye base ions mudumbu remukati, inducing fluid kutakura kupinda mudumbu remukati, uye kuwedzera gastrointestinal peristalsis.Mechanism of action Pucanatide uye metabolites yayo inoshanda inosunga kune GC-C enzymes uye inoshanda munharaunda panzvimbo ye lumen ye intestinal epithelial masero.Kuitwa kweGC-C enzyme kunowedzera kuwanda kweiyo intracellular uye extracellular cyclic guanosine phosphate (cGMP), nepo kuwedzera kweiyo intracellular cGMP concentration inonyanya kukurudzira kuburitswa kwechloride uye bicarbonate mumatumbo lumen kuburikidza neion chiteshi activation yecystic fibrosis transmembrane regulatory. factor (CFTR), iyo inowedzera uye inomhanyisa mafambiro emudumbu.