CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

Prokanatide (Plecanatide) waa daawo cusub oo saameynaysa guanylate cyclase, taas oo kicin karta dheecaanka xiidmaha ee dareeraha mindhicirka waxayna dardargelisaa saxarada.Polypeptide afka laga qaato oo ka kooban 16 amino acids oo loogu talagalay in lagu ekaysiiyo peptide caloosha iyo mindhicirka bini aadamka, uranyin.Pucanatide, oo asal ahaan ay soo saartay Callisto Pharmaceuticals oo loo wareejiyay dawooyinka Synergy, waxaa oggolaatay Maamulka Cuntada iyo Dawooyinka ee Maraykanka (FDA) daaweynta CIC ee dadka waaweyn Janaayo 19, 2017. Pucanatide waa analogues uroguanylin, buug kiimiko polypeptide wareeg ah oo ka kooban 16 amino acids.Waxay u shaqeysaa sidii agonist guanylate cyclase agonist oo loogu talagalay soosaarka soodhiyamka, nidaaminta aashitada iyo ion saldhigga ee mareenka caloosha iyo mindhicirka, soo jiidashada dareeraha dareeraha ee mareenka caloosha iyo mindhicirka, iyo kordhinta peristalsis caloosha.Farsamaynta ficilka Pucanatide iyo dheef-shiid kiimikaadkeeda firfircoon waxay ku xidhaan enzymes GC-C waxayna u dhaqmaan gudaha dusha lumen ee unugyada epithelial mindhicirka.Firfircoonida GC-C enzyme waxay kordhisaa fiirsashada intracellular iyo extracellular cyclic phosphate (cGMP), halka kororka fiirsashada cGMP intracellular ay inta badan kiciso dheecaanka chloride iyo bicarbonate gudaha lumen mindhicirka iyada oo loo marayo kanaalka ion ee xakamaynta cystic fibrosis transmembrane. factor (CFTR), kaas oo kordhiya oo dedejiya socodka dheecaanka mindhicirka.