CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

Prokanatide (Plecanatide) ndi mankhwala atsopano omwe amakhudza guanylate cyclase, omwe amatha kulimbikitsa kutuluka kwa m'mimba m'matumbo ndikufulumizitsa kuchotsedwa.Polypeptide wapakamwa wopangidwa ndi ma amino acid 16 opangidwa kuti azitsanzira peptide ya m'mimba yamunthu, uranyin.Pucanatide, yopangidwa ndi Callisto Pharmaceuticals ndipo idasamutsidwa ku Synergy Pharmaceuticals, idavomerezedwa ndi US Food and Drug Administration (FDA) kuti ichiritse CIC mwa akulu pa Januware 19, 2017. Pucanatide ndi analogues a uroguanylin, cyclic polypeptide Chemicalbook yomwe ili ndi Chemicalbook 16 amino zidulo.Imakhala ngati guanylate cyclase receptor agonist ya sodium excretion, kuwongolera asidi ndi ma ayoni oyambira m'matumbo am'mimba, kupangitsa kuyenda kwamadzimadzi kulowa m'matumbo am'mimba, ndikuwonjezera m'mimba peristalsis.Limagwirira ntchito Pucanatide ndi yogwira metabolites kumangiriza kwa GC-C michere ndi kuchita kwanuko pa lumen pamwamba matumbo epithelial maselo.Kutsegula kwa enzyme ya GC-C kumawonjezera kuchuluka kwa intracellular ndi extracellular cyclic guanosine phosphate (cGMP), pomwe kuchuluka kwa intracellular cGMP kumapangitsa kuti chloride ndi bicarbonate zilowe m'matumbo a lumen kudzera mu ion channel activation ya cystic fibrosis transmembrane regulatory. factor (CFTR), yomwe imachulukitsa ndikufulumizitsa kutuluka kwa m'mimba.