CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

Ko te Prokanatide (Plecanatide) he rongoa hou e pa ana ki te guanylate cyclase, ka taea te whakaihiihi i te urunga o te whekau o te whekau me te whakatere i te whakahekenga.He polypeptide-waha he 16 nga waikawa amino i hangaia hei whakatauira i te peptide gastrointestinal tangata, uranyin.Ko Pucanatide, i hangaia e Callisto Pharmaceuticals me te whakawhiti ki te Synergy Pharmaceuticals, i whakaaetia e te US Food and Drug Administration (FDA) mo te maimoatanga o te CIC i roto i nga pakeke i te Hanuere 19, 2017. Ko Pucanatide he analogues o te uroguanylin, he polypeptide cyclic Chemicalbook kei roto. 16 waikawa amino.Ko te mahi hei agonist kaiwhakawhiwhi cyclase guanylate mo te whakakore i te konutai, te whakahaere i te waikawa me nga katote turanga i roto i te waahanga o te kopu, te whakaawe i te kawe wai ki roto i te kopa, me te whakanui ake i te peristalsis gastrointestinal.Hangaia o te mahi Pucanatide me ona metabolites kaha herea ki GC-C whākōkī me te mahi rohe i runga i te mata lumen o ngā pūtau epithelial intestinal.Ko te whakahoahoatanga o te GC-C enzyme ka whakanui ake i te kukū o te guanosine phosphate intracellular me extracellular cyclic guanosine phosphate (cGMP), i te mea ko te pikinga o te kukū cGMP intracellular te nuinga o te whakaongaonga i te hunanga o te chloride me te bicarbonate ki roto i te lumen intestinal na roto i te hongere katote whakahohenga o te cystic fibrosis transmembrane ture. tauwehe (CFTR), ka piki ake, ka tere ake te rere o te wai intestinal.