CAS : 467426-54-6 Plecanatide Prikanatide ATCH (1-39) Plecanatide Impurtiy CAS TSIS TAU: 467426-54-6

Prokanatide (Plecanatide) yog ib yam tshuaj tshiab cuam tshuam rau guanylate cyclase, uas tuaj yeem ua rau lub plab hnyuv tso tawm ntawm cov kua dej hauv plab thiab ua kom lub plab zom mov.Lub qhov ncauj polypeptide muaj li ntawm 16 amino acids tsim los ua raws li tib neeg txoj hnyuv peptide, uranyin.Pucanatide, Ameslikas tsim los ntawm Callisto Pharmaceuticals thiab pauv mus rau Synergy Pharmaceuticals, tau pom zoo los ntawm US Food and Drug Administration (FDA) rau kev kho CIC rau cov neeg laus thaum Lub Ib Hlis 19, 2017. Pucanatide yog ib qho analogues ntawm uroguanylin, cyclic polypeptide Chemicalbook uas muaj 16 amino acids.Nws ua raws li ib tug guanylate cyclase receptor agonist rau sodium excretion, tswj cov kua qaub thiab cov hauv paus ions nyob rau hauv lub plab hnyuv ib ntsuj av, inducing dej thauj mus rau hauv lub plab hnyuv ib ntsuj av, thiab nce gastrointestinal peristalsis.Mechanism ntawm kev txiav txim Pucanatide thiab nws cov nquag metabolites khi rau GC-C enzymes thiab ua haujlwm hauv zos ntawm lumen ntawm txoj hnyuv epithelial hlwb.Kev ua haujlwm ntawm GC-C enzyme ua rau kom cov concentration ntawm intracellular thiab extracellular cyclic guanosine phosphate (cGMP), thaum qhov nce ntawm intracellular cGMP concentration feem ntau nkoos lub zais ntawm chloride thiab bicarbonate rau hauv plab hnyuv lumen los ntawm ion channel activation ntawm cystic fibrosis transmembrane regulatory. qhov tseem ceeb (CFTR), uas ua rau kom nce thiab ua kom lub plab zom mov.