CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

I-Prokanatide (i-Plecanatide) iyeza elitsha elichaphazela i-guanylate cyclase, enokuvuselela ukukhutshwa kwamathumbu emathunjini kunye nokukhawulezisa ukuchithwa.I-polypeptide yomlomo eyenziwe nge-16 amino acids eyenzelwe ukulinganisa i-peptide yesisu somntu, i-uranyin.I-Pucanatide, eyaqalwa yiCallisto Pharmaceuticals kwaye idluliselwe kwi-Synergy Pharmaceuticals, yavunywa yi-US Food and Drug Administration (FDA) yonyango lwe-CIC kubantu abadala ngoJanuwari 19, 2017. I-Pucanatide i-analogues ye-uroguanylin, i-cyclic polypeptide Chemicalbook equlethe 16 amino acids.Isebenza njenge-guanylate cyclase receptor agonist ye-sodium excretion, ilawula i-asidi kunye ne-ion yesiseko kwi-gastrointestinal tract, ihambisa ukuthuthwa kwamanzi kwi-gastrointestinal tract, kunye nokwandisa i-peristalsis yesisu.I-Mechanism of action Pucanatide kunye ne-metabolites yayo esebenzayo ibophelela kwi-enzymes ye-GC-C kwaye isebenze kwindawo kwindawo ye-lumen yeeseli ze-epithelial zamathumbu.Ukusetyenziswa kwe-enzyme ye-GC-C kwandisa ukuxinana kwe-intracellular kunye ne-extracellular cyclic guanosine phosphate (cGMP), ngelixa ukwanda kwe-intracellular cGMP concentration ivuselela ukukhutshwa kwe-chloride kunye ne-bicarbonate kwi-lumen yamathumbu ngokusebenzisa i-ion channel activation ye-cystic fibrosis transmembrane regulatory. factor (CFTR), eyandisa kwaye ikhawulezise ukudlula ulwelo emathunjini.