CAS: 467426-54-6 Plecanatide Prikanatide; ATCH (1-39) Plecanatide Impurtiy

Prokanatide (Plecanatide) ni umuti mushya wibasira guanylate cyclase, ushobora gutera ururenda rwo mu mara rwamazi yo munda kandi byihutisha umwanda.Polypeptide yo mu kanwa igizwe na aside amine 16 yagenewe kwigana peptide ya gastrointestinal yumuntu, uranyin.Pucanatide, yakozwe bwa mbere na Pharmaceuticals ya Callisto yimurirwa muri Synergy Pharmaceuticals, yemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA) cyo kuvura CIC ku bantu bakuru ku ya 19 Mutarama 2017. Pucanatide ni ikigereranyo cya uroguanylin, igitabo cyitwa Chemical polypeptide Chemical 16 aside amine.Ikora nka guanylate cyclase reseptor agonist yo gusohora sodium, igenga aside na ion zifatizo mu nzira ya gastrointestinal, itera ubwikorezi bwamazi mu nzira ya gastrointestinal, no kongera peristalisite gastrointestinal.Uburyo bwibikorwa Pucanatide hamwe na metabolite ikora ihuza imisemburo ya GC-C kandi igakorera mugace hejuru yumubiri wa selile epithelial selile.Gukora imisemburo ya GC-C byongera ubukana bwa cyclica guanosine fosifate (cGMP), hamwe no kwiyongera kwa cGMP yo mu nda itera ahanini gusohora kwa chloride na bicarbonate mu mara yo mu mara binyuze mu miyoboro ya ion ikora ya cystic fibrosis transmembrane kintu (CFTR), cyiyongera kandi cyihuta kunyura mumazi yo munda.