CAS: 467426-54-6 Plecanatide Prikanatide; ATCH (1-39) Plecanatide Impurtiy

Prokanatide (Plecanatide) wani sabon magani ne da ke shafar guanylate cyclase, wanda zai iya tada fitar hanji na ruwan hanji da kuma hanzarta bacewar.Polypeptide na baka wanda ya ƙunshi amino acid 16 da aka tsara don kwaikwayi peptide na ciki na ɗan adam, uranyin.Pucanatide, wanda Callisto Pharmaceuticals ya samo asali ne kuma ya koma Synergy Pharmaceuticals, Hukumar Abinci da Magunguna ta Amurka (FDA) ta amince da ita don kula da CIC a cikin manya a ranar 19 ga Janairu, 2017. Pucanatide analogues ne na uroguanylin, littafin sinadarai na cyclic polypeptide wanda ke dauke da shi. 16 amino acid.Yana aiki a matsayin agonist mai karɓa na guanylate cyclase don cirewar sodium, daidaita acid da ions tushe a cikin gastrointestinal tract, haifar da jigilar ruwa zuwa cikin gastrointestinal fili, da kuma kara yawan peristalsis na ciki.Tsarin aikin Pucanatide da metabolites ɗin sa masu aiki suna ɗaure ga enzymes GC-C kuma suna aiki a cikin gida a saman lumen na ƙwayoyin epithelial na hanji.Kunnawar GC-C enzyme yana ƙaruwa da haɓakar intracellular da extracellular cyclic guanosine phosphate (cGMP), yayin da karuwar ƙwayar cGMP na intracellular galibi yana haɓaka ɓoyewar chloride da bicarbonate a cikin lumen na hanji ta hanyar tashar ion kunna tsarin cystic fibrosis transmembrane. factor (CFTR), wanda ke ƙaruwa da kuma hanzarta tafiyar ruwan hanji.