CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

ʻO ka Prokanatide (Plecanatide) kahi lāʻau hou e pili ana i ka guanylate cyclase, hiki ke hoʻoulu i ka huna ʻana o ka ʻōpū o ka wai ʻōpū a hoʻolalelale i ka defecation.He polypeptide waha i haku ʻia me 16 amino acids i hoʻolālā ʻia e hoʻohālike i ka peptide gastrointestinal kanaka, uranyin.ʻO Pucanatide, i hoʻokumu mua ʻia e Callisto Pharmaceuticals a ua hoʻololi ʻia i Synergy Pharmaceuticals, ua ʻae ʻia e ka US Food and Drug Administration (FDA) no ka mālama ʻana iā CIC i nā pākeke ma Ianuali 19, 2017. 16 amino acids.Hana ia ma ke ʻano he guanylate cyclase receptor agonist no ka sodium excretion, hoʻoponopono i ka waikawa a me nā ion base i loko o ka ʻōpū o ka ʻōpū, hoʻoulu i ka lawe ʻana i ka wai i loko o ka ʻōpū, a me ka hoʻonui ʻana i ka peristalsis gastrointestinal.ʻO ka hana o ka Pucanatide a me kāna mau metabolites ikaika e hoʻopaʻa i nā enzymes GC-C a hana ma ka ʻāina ma ka ʻili lumen o nā cell epithelial intestinal.ʻO ka hoʻoulu ʻana o ka enzyme GC-C e hoʻonui i ka ʻike o ka intracellular a me ka extracellular cyclic guanosine phosphate (cGMP), aʻo ka hoʻonui ʻana o ka intracellular cGMP concentration e hoʻoulu nui i ka huna ʻana o ka chloride a me ka bicarbonate i loko o ka lumen intestinal ma o ke kahawai ion activation o cystic fibrosis transmembrane regulatory kumu (CFTR), ka mea e hoʻonui a hoʻomāhuahua i ka hele ʻana o ka wai ʻōpū.