CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

Prokanatide (Plecanatide) ke sethethefatsi se secha se amang guanylate cyclase, se ka susumetsang ho ntšoa ha mokelikeli oa mala le ho potlakisa ho ntša bohloeki.Polypeptide ea molomo e entsoeng ka li-amino acid tse 16 tse etselitsoeng ho etsisa peptide ea ka mpeng ea motho, uranyin.Pucanatide, e qapiloeng ke Callisto Pharmaceuticals le ho fetisetsoa ho Synergy Pharmaceuticals, e amohetsoe ke US Food and Drug Administration (FDA) bakeng sa phekolo ea CIC ho batho ba baholo ka January 19, 2017. Pucanatide ke analogues ea uroguanylin, cyclic polypeptide Chemicalbook e nang le Chemicalbook 16 li-amino acid.E sebetsa joalo ka guanylate cyclase receptor agonist bakeng sa ho tsoa ha sodium, ho laola asiti le li-ion tsa motheo ka har'a pampiri ea mala, ho kenya mokelikeli ka har'a pampitšana ea mala, le ho eketsa peristalsis ea mala.Mokhoa oa ts'ebetso oa Pucanatide le li-metabolite tsa eona tse sebetsang li tlama ho li-enzyme tsa GC-C mme li sebetsa sebakeng sa heno holim'a lumen ea lisele tsa epithelial tsa mala.Ts'ebetso ea enzyme ea GC-C e eketsa bongata ba intracellular le extracellular cyclic guanosine phosphate (cGMP), ha keketseho ea intracellular cGMP e hlohlelletsa secretion ea chloride le bicarbonate ka har'a lumen ea mala ka ts'ebetso ea ion channel ea cystic fibrosis transmembrane regulatory. factor (CFTR), e eketsang le ho potlakisa ho feta ha mokelikeli oa mala.