I-Teduglutide CAS:197922-42-2 Teduglutide(ALX-0600) Revestive

Umsebenzi:
I-Teduglutide, eyaziwa ngesiNgisi ngokuthi i-Teduglutide, iyi-analogue ye-glucagon-like peptide 2 (GLP-2), i-hormone eyenzeka ngokwemvelo enciphisa ukuphuma nokuphuma kwesisu futhi ilawule ukukhula, ukwanda, nokulungiswa kwamaseli olwelweni lwamathumbu.Umuthi ukhulisa inani lala maseli, okwandisa ukumuncwa emathunjini amancane futhi anciphise isifo sohudo.
Ukulungiselela:
Ukwakheka kwesakhiwo esiyindandatho esinamalungu amahlanu kuhlobene kakhulu ne-amino acid efanele ye-Asp noma i-Asn, futhi i-Gly iyisakhiwo esiyindandatho esakheka kalula lapho i-Gly ihlanganiswa ngaphambi kwe-Asp ngenxa yokuntuleka kweqembu elivikelayo kanye nesithiyo esiphansi se-steric ohlangothini. iketango.Ngakho-ke, akunakugwenywa ukuthi indlela yokuhlanganisa yokulandelana izokwenza i-N-terminal amino acids ye-Tedulu Chemicalbook peptide yakhe indandatho enamalungu amahlanu ohlelweni lokuhlanganiswa, okuzonciphisa ubumsulwa.Ngakho-ke, ukuze kuxazululwe inkinga yokuwohloka kwe-Asp-Gly fragment, ingxenye evikelwe ngokugcwele enesakhiwo esiboniswe ku-SEQIDNO:2 yaqala ukuhlanganiswa ngokuhlanganisa izingcezu.Ucezu oluvikelwe ngokugcwele lwaluyi-amino acid yokuqala ~ yesine ye-N-terminal ye-tidulutide, okuhlanganisa nesakhiwo se-Asp-Gly, kwase kuhlanzwa ucezwana oluvikelwe ngokugcwele.Ucezu oluhlanzwe ngokugcwele lwaluyisigaba esiqinile esihlanganiswe ne-peptide resin enesakhiwo esiboniswe ku-SEQIDNO:12, futhi ukuqhekeka kokugcina kwenziwa ukuze kutholwe i-tidurotide.