CAS: 467426-54-6 Plecanatide Prikanatide;ATCH(1-39) Plecanatide Impurtiy

O le Prokanatide (Plecanatide) o se vailaʻau fou e aʻafia ai le guanylate cyclase, lea e mafai ona faʻaosofia ai le faʻamalo o le manava o le manava ma faʻavavevave ai le feʻai.O se polypeptide tautala e aofia ai 16 amino acids ua fuafuaina e faʻataʻitaʻiina le peptide gastrointestinal o le tagata, uranyin.Pucanatide, na amataina e Callisto Pharmaceuticals ma siitia atu i Synergy Pharmaceuticals, na faamaonia e le US Food and Drug Administration (FDA) mo le togafitia o le CIC i tagata matutua ia Ianuari 19, 2017. Pucanatide o se analogues o le uroguanylin, o se cyclic polypeptide Chemicalbook o loʻo i ai. 16 amino acids.E galue e pei o le guanylate cyclase receptor agonist mo le sodium excretion, faatonutonuina acid ma faavae ions i totonu o le gastrointestinal tract, faaosofia le felauaiga o le vai i totonu o le gastrointestinal tract, ma le faateleina o le peristalsis gastrointestinal.Mechanism of action Pucanatide ma ana metabolites malosi e fusifusia i GC-C enzymes ma galue i le lotoifale i luga o le lumen luga o sela epithelial intestinal.O le faʻagaoioia o le GC-C enzyme e faʻateleina ai le faʻaogaina o le intracellular ma extracellular cyclic guanosine phosphate (cGMP), ae o le faʻateleina o le intracellular cGMP concentration e faʻaosofia ai le faʻaogaina o le chloride ma le bicarbonate i totonu o le intestinal lumen e ala i le faʻagaioiina o alavai o le cystic fibrosis transmembrane regulatory. factor (CFTR), lea e faʻateleina ma faʻavavevave ai le ala o le sua o le intestinal.