I-Teduglutide CAS:197922-42-2 Teduglutide(ALX-0600) Revestive

Umsebenzi:
I-Teduglutide, eyaziwa ngesiNgesi njenge-Teduglutide, i-analogue ye-glucagon-like peptide 2 (GLP-2), ihomoni eyenzeka ngokwemvelo enciphisa ukukhupha isisu kunye nokukhupha kunye nokulawula ukukhula, ukwanda, kunye nokulungiswa kweeseli kwi-intestinal lining.Ichiza kwandisa inani ezi seli, okwandisa ukufunxa emathunjini amancinci kunye nokunciphisa urhudo.
Ukulungiselela:
Ukwenziwa kwesakhiwo seringi esinamalungu amahlanu sinxulumene kakhulu ne-amino acid echanekileyo ye-Asp okanye i-Asn, kwaye i-Gly sesona sakhiwo sisesenziwe lula xa i-Gly idityaniswa ngaphambi kwe-Asp ngenxa yokungabikho kweqela elikhuselayo kunye nesithintelo esisezantsi se-steric ecaleni. ikhonkco.Ngoko ke, akunakuphepheka ukuba indlela yokudibanisa ngokulandelelana iya kwenza i-N-terminal amino acids ye-Tedulu Chemicalbook peptide yenza i-ring-five-member in process of synthesis, eya kunciphisa ukucoceka.Ngoko ke, ukwenzela ukucombulula ingxaki yokuthotywa kwe-Asp-Gly fragment, iqhekeza elikhuselwe ngokupheleleyo kunye nesakhiwo esiboniswe kwi-SEQIDNO: i-2 yaqala ukuhlanganiswa ngokudibanisa iqhekeza.Iqhekeza elikhuselwe ngokupheleleyo yayiyeyokuqala ~ yesine ye-amino acid yokuqala ye-N-terminal ye-tidulutide, kubandakanywa nolwakhiwo lwe-Asp-Gly, emva koko iqhekeza elikhuselwe ngokupheleleyo lacocwa.Isiqwenga esihlanjululweyo esikhuselwe ngokupheleleyo sasiyisigaba esiqinileyo kunye ne-fragment peptide resin kunye nesakhiwo esiboniswe kwi-SEQIDNO: i-12, kwaye i-cleavage yokugqibela yenziwa ukufumana i-tidurotide.