Teduglutide CAS: 197922-42-2 Teduglutide (ALX-0600) Revestive

Ntchito:
Teduglutide, yomwe imadziwika mu Chingerezi kuti Teduglutide, ndi analogue ya glucagon-ngati peptide 2 (GLP-2), mahomoni opangidwa mwachilengedwe omwe amachepetsa kutulutsa m'mimba komanso kutulutsa komanso kuwongolera kukula, kuchulukana, komanso kukonza ma cell m'matumbo am'mimba.Mankhwalawa amawonjezera kuchuluka kwa maselowa, omwe amawonjezera kuyamwa m'matumbo aang'ono ndikuchepetsa kutsekula m'mimba.
Kukonzekera:
Mapangidwe a mphete yamagulu asanu amagwirizana kwambiri ndi amino acid yoyenera ya Asp kapena Asn, ndipo Gly ndiyomwe imapangidwira mosavuta pamene Gly imagwirizanitsidwa pamaso pa Asp chifukwa cha kusowa kwa gulu loteteza komanso cholepheretsa chochepa cha steric pambali. unyolo.Choncho, n'zosapeŵeka kuti njira yophatikizira yotsatizana imapangitsa kuti N-terminal amino acids a Tedulu Chemicalbook peptide apange mphete ya mamembala asanu popanga kaphatikizidwe, zomwe zidzachepetse chiyero.Chifukwa chake, kuti athetse vuto lowonongeka lachidutswa cha Asp-Gly, chidutswa chotetezedwa kwathunthu ndi kapangidwe kamene kamawonetsedwa mu SEQIDNO: 2 idapangidwa koyamba ndikuphatikizana.Chidutswa chotetezedwa bwino chinali choyamba ~ chachinayi cha amino acid cha N-terminal ya tidulutide, kuphatikiza kapangidwe ka Asp-Gly, ndiyeno chidutswa chotetezedwa bwino chidayeretsedwa.Chidutswa choyeretsedwa chotetezedwa bwino chinali cholimba chophatikizidwa ndi utomoni wa peptide wokhala ndi mawonekedwe omwe akuwonetsedwa mu SEQIDNO:12, ndipo cleavage yomaliza idachitidwa kuti ipeze tidurotide.