Teduglutide CAS: 197922-42-2 Teduglutide (ALX-0600) Revestive

Aiki:
Teduglutide, wanda aka fi sani da Turanci a matsayin Teduglutide, analog ne na glucagon-kamar peptide 2 (GLP-2), wani hormone da ke faruwa ta halitta wanda ke rage zubar da ciki da ɓoyewa kuma yana daidaita girma, yaduwa, da gyaran sel a cikin rufin hanji.Magungunan yana ƙara yawan adadin waɗannan ƙwayoyin, wanda ke ƙara yawan sha a cikin ƙananan hanji kuma yana rage gudawa.
Shiri:
Samar da tsarin zobe mai mambobi biyar yana da alaƙa da madaidaicin amino acid na Asp ko Asn, kuma Gly shine tsarin zobe mafi sauƙi da aka samu lokacin da aka haɗa Gly kafin Asp saboda rashin ƙungiyar kariya da ƙarancin tsangwama a gefe. sarkar.Don haka, babu makawa hanyar haɗakarwa ta jere za ta sa amino acid ɗin Tedulu Chemicalbook peptide na N-terminal su zama zobe mai mambobi biyar a cikin tsarin haɗin gwiwa, wanda zai rage tsafta.Sabili da haka, don magance matsalar lalatawar ɓangarorin Asp-Gly, wani yanki mai cikakken kariya tare da tsarin da aka nuna a cikin SEQIDNO: 2 an fara haɗa shi ta hanyar haɗakarwa.Cikakken kariya shine farkon ~ na huɗu amino acid na N-terminal na tidulutide, gami da tsarin Asp-Gly, sannan aka tsarkake guntun da aka kiyaye.Tsabtataccen tsararren cikakken kariya ya kasance mai ƙarfi-lokaci tare da gutsuttsura peptide resin tare da tsarin da aka nuna a cikin SEQIDNO:12, kuma an gudanar da tsagewar ƙarshe don samun tidurotide.