Calcitonin salmon CAS 47931-85-1 Salmotonin Thyrocalcitonin
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Isici:
| Igama elivamile | i-salmon calcitonin | Igama lesiNgisi | I-Salmon Calcitonin Acetate |
|---|---|---|---|
| Inombolo ye-CAS | 47931-85-1 |
| Ukuminyana | 1.5±0.1g/cm3 |
|---|---|
| Ifomula yamangqamuzana | C145H240N44O48S2 |
| Isisindo samangqamuzana | 3431.853 |
| Isisindo esinembile | 3429.713379 |
| I-PSA | 1558.81000 |
| I-LogP | -12.48 |
| Izici zokubukeka | impushana |
| Inkomba ye-refractive | 1.677 |
| Izimo zokugcina | Ivaliwe, igcinwe ku -18 ºC |
| Ukuzinza | Akukho ukubola, akukho ukusabela okuyingozi okwaziwayo uma kusetshenziswa futhi kugcinwa ngokuya ngemininingwane |
| Ukuncibilika kwamanzi | 0.05 M i-acetic acid: 1 mg/mL, icacile, ayinambala |
Ukusetshenziswa:
I-Calcitonin Salmon iyi-hormone ye-polypeptide ekhishwa yi-ultimobranchial gland ye-salmon.Ingowomndeni wamaprotheni afana ne-calcitonin futhi ingasetshenziswa ukwelapha isifo se-Paget's of bone, i-postmenopausal osteoporosis (amathambo aphukayo noma aphukayo), noma amazinga aphezulu e-calcium egazini (hypercalcemia).Kubonakala sengathi inezenzo ezicishe zifane nama-calcitonin emvelaphi yezilwane ezincelisayo, kodwa amandla ayo nge-mg makhulu futhi inesikhathi eside sokusebenza.Isebenza ikakhulukazi ngokuvimbela i-osteoclastic bone resorption, ukunciphisa i-serum calcium, nokwandisa ukuphuma kwezinso kwe-phosphate, i-calcium, i-sodium magnesium ne-potassium ngokunciphisa ukumuncwa kabusha kwe-tubular.
Kubantu, i-salmon calcitonin isebenza kakhulu kune-analog yayo yomuntu.
I-Calcitonin (i-salmon) inomthelela omuhle ekwakhiweni kabusha kwamathambo kanye nokuminyana kwamathambo ngenxa yomphumela wayo ovimbelayo emsebenzini we-osteoclast.Umphumela onenzuzo we-salmon calcitonin ekwelapheni ukuphuka kwamathambo e-osteoporotic nakho kungenxa yokukhuthazwa kwesigaba se-cartilaginous sokuphulukiswa kokuphuka kanye nokukhulula ubuhlungu.
I-salmon ye-Calcitonin ingasetshenziselwa ukuhlola i-calcitonin receptor/cAMP ukuze kuhlolwe ubukhona be-calcitonin receptors evezwa amaseli e-TRAP+. i-salmon calcitonin (sCT) kusithiyo se-gastric mucosal kumagundane avezwe ekucindezelekeni okubandayo + ukuzibamba (CRS).
