Kalemona Calcitonin CAS 47931-85-1 Salmotonin Thyrocalcitonin
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ʻano:
| inoa maʻamau | salmon calcitonin | inoa Pelekane | Salmon Calcitonin Acetate |
|---|---|---|---|
| Helu CAS | 47931-85-1 |
| ʻO ka mānoanoa | 1.5±0.1g/cm3 |
|---|---|
| ʻAno molekala | C145H240N44O48S2 |
| Kaumaha molekula | 3431.853 |
| Nuipa pololei | 3429.713379 |
| PSA | 1558.81000 |
| LogP | -12.48 |
| Nā hiʻohiʻona hiʻohiʻona | pauda |
| Hōʻike hōʻike | 1.677 |
| Nā kūlana mālama | Hoʻopaʻa ʻia, mālama ma -18 ºC |
| Paʻa | ʻAʻohe decomposition, ʻaʻohe hopena ʻino i ʻike ʻia inā hoʻohana a mālama ʻia e like me nā kikoʻī |
| Ka hoʻoheheʻe wai | 0.05 M acetic acid: 1 mg/mL, akaka, kala ʻole |
Hoʻohana:
ʻO Calcitonin Salmon kahi hormone polypeptide i huna ʻia e ka ultimobranchial gland o ka salmon.No ka ʻohana protein e like me ka calcitonin a hiki ke hoʻohana ʻia no ka mālama ʻana i ka maʻi iwi o Paget, osteoporosis postmenopausal (iwi palupalu a palupalu), a i ʻole kiʻekiʻe o ka calcium i loko o ke koko (hypercalcemia).ʻIke ʻia he mau hana like ʻole me nā calcitonins o ke kumu mammalian, akā ʻoi aku kona ikaika i kēlā me kēia mg a ʻoi aku ka lōʻihi o ka hana.Hana nui ia ma ke kāohi ʻana i ka hoʻihoʻi ʻana o ka iwi osteoclastic, hoʻemi i ka calcium serum, a me ka hoʻonui ʻana i ka renal excretion o phosphate, calcium, sodium magnesium a me ka potassium ma ka hoʻemi ʻana i ka reabsorption tubular.
I loko o ke kanaka, ʻoi aku ka ikaika o ka salmon calcitonin ma mua o kāna analog kanaka.
Hoʻoikaika maikaʻi ʻo Calcitonin (salmon) i ka hoʻoponopono hou ʻana o ka iwi a me ka nui o ka iwi ma muli o kona hopena pale i ka hana osteoclast.ʻO ka hopena maikaʻi o ka salmon calcitonin i ka mālama ʻana i nā haʻihaʻi o ka iwi osteoporotic ma muli o ka hoʻolaha ʻana i ka māhele cartilaginous o ka hoʻōla ʻana a me ka hoʻomaha ʻana i ka ʻeha.
Hiki ke hoʻohana ʻia ka salmon Calcitonin no ka calcitonin receptor/cAMP assay no ka loiloi ʻana i ka hiki ʻana mai o nā calcitonin receptors i hōʻike ʻia e TRAP + cell. Hiki ke hoʻohana ʻia ka huahana ma ke ʻano he pūhui hoʻāʻo no ke aʻo ʻana a me ka hoʻohālikelike ʻana i ka hopena o ka calcitonin gene related peptide (CGRP) a ʻO ka salmon calcitonin (sCT) ma ka ʻāʻī o ka ʻōpū o ka ʻiole i ʻike ʻia i ke anu + kaohi ʻana (CRS).
