Calcitonin salmon CAS 47931-85-1 Salmotonin Thyrocalcitonin
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Characteristic:
| Common name | salmon calcitonin | English name | Salmon Calcitonin Acetate |
|---|---|---|---|
| CAS number | 47931-85-1 |
| Density | 1.5±0.1g/cm3 |
|---|---|
| Molecular formula | C 145 H 240 N 44 O 48 S 2 |
| Molecular weight | 3431.853 |
| Accurate mass | 3429.713379 |
| PSA | 1558.81000 |
| LogP | -12.48 |
| Appearance traits | powder |
| Refractive index | 1.677 |
| Storage conditions | Sealed, store at -18 ºC |
| Stability | No decomposition, no known hazardous reactions if used and stored according to specifications |
| Water solubility | 0.05 M acetic acid: 1 mg/mL, clear, colorless |
Usage:
Calcitonin Salmon is a polypeptide hormone secreted by the ultimobranchial gland of salmon. It belongs to the calcitonin-like protein family and can be used to treat Paget’s disease of bone, postmenopausal osteoporosis(fragile or brittle bones), or high levels of calcium in the blood (hypercalcemia). It appears to have actions essentially identical to calcitonins of mammalian origin, but its potency per mg is greater and it has a longer duration of action. It works mainly by Inhibiting osteoclastic bone resorption, decreasing serum calcium, and increasing renal excretion of phosphate, calcium, sodium magnesium and potassium by decreasing tubular reabsorption.
In humans, salmon calcitonin is more active than its human analog.
Calcitonin (salmon) positively influences bone remodelling and bone mass density due to its inhibiting effect on osteoclast activity. The beneficial effect of salmon calcitonin in the treatment of osteoporotic bone fractures is also due to the promotion of the cartilaginous phase of fracture healing and to pain relief.
Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).
