Calcitonin salmon CAS 47931-85-1 Salmotonin Thyrocalcitonin
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Uphawu:
| Igama eliqhelekileyo | isalmon calcitonin | Igama lesiNgesi | Salmon Calcitonin Acetate |
|---|---|---|---|
| Inombolo yeCAS | 47931-85-1 |
| Ukuxinana | 1.5±0.1g/cm3 |
|---|---|
| Ifomula yemolekyuli | C145H240N44O48S2 |
| Ubunzima bemolekyuli | 3431.853 |
| Ubunzima obuchanekileyo | 3429.713379 |
| PSA | 1558.81000 |
| LogP | -12.48 |
| Iimpawu zenkangeleko | umgubo |
| Isalathiso sokuqhafaza | 1.677 |
| Iimeko zokugcina | Itywiniwe, igcine kwi -18 ºC |
| Uzinzo | Akukho ukubola, akukho zimpendulo eziyingozi zaziwayo ukuba zisetyenziswe kwaye zigcinwe ngokweenkcukacha |
| Ukunyibilika kwamanzi | I-0.05 M i-acetic acid: 1 mg / mL, ecacileyo, engenambala |
Ukusetyenziswa:
I-Calcitonin Salmon yihomoni ye-polypeptide ekhutshwe yi-ultimobranchial gland ye-salmon.Iphuma kusapho lweprotheyini efana ne-calcitonin kwaye ingasetyenziselwa ukunyanga isifo se-Paget's of bone, i-postmenopausal osteoporosis (i-fragile okanye amathambo anqabileyo), okanye amanqanaba aphezulu e-calcium egazini (hypercalcemia).Kubonakala ngathi kunezenzo ezifana ne-calcitonins zemvelaphi ye-mammalian, kodwa amandla ayo nge-mg makhulu kwaye inobude bexesha elide lesenzo.Isebenza ikakhulu ngokuthintela i-osteoclastic bone resorption, ukunciphisa i-serum calcium, kunye nokwandisa ukukhutshwa kwezintso zephosphate, i-calcium, i-sodium magnesium kunye ne-potassium ngokunciphisa ukuphindaphinda kwe-tubular.
Ebantwini, i-salmon calcitonin isebenza ngakumbi kune-analog yayo yomntu.
I-Calcitonin (i-salmon) ichaphazela ngokufanelekileyo ukulungiswa kwamathambo kunye nobuninzi bethambo ngenxa yempembelelo yayo yokuthintela kumsebenzi we-osteoclast.Impembelelo enenzuzo ye-salmon calcitonin kunyango lwe-osteoporotic bone fractures nayo ibangelwa ukukhuthazwa kwesigaba se-cartilaginous sokuphulukisa ukuphuka kunye nokunciphisa intlungu.
I-salmon ye-calcitonin ingasetyenziselwa i-calcitonin receptor / i-cAMP assay yokuvavanya ubukho be-calcitonin receptors echazwe yi-TRAP + iiseli. isalmon calcitonin (sCT) kwisithintelo se-gastric mucosal kwiimpuku ezivezwe kubanda + uxinzelelo lokuzibamba (CRS).
