Calcitonin nsomba ya CAS 47931-85-1 Salmotonin Thyrocalcitonin
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Khalidwe:
| Dzina lodziwika | nsomba ya calcitonin | Dzina lachingerezi | Salmon Calcitonin Acetate |
|---|---|---|---|
| Nambala ya CAS | 47931-85-1 |
| Kuchulukana | 1.5±0.1g/cm3 |
|---|---|
| Molecular formula | C145H240N44O48S2 |
| Kulemera kwa maselo | 3431.853 |
| Misa yolondola | 3429.713379 |
| PSA | 1558.81000 |
| LogP | -12.48 |
| Mawonekedwe ake | ufa |
| Refractive index | 1.677 |
| Zosungirako | Osindikizidwa, sungani pa -18 ºC |
| Kukhazikika | Palibe kuwola, palibe zowopsa zomwe zimadziwika ngati zitagwiritsidwa ntchito ndikusungidwa molingana ndi zomwe mukufuna |
| Kusungunuka kwamadzi | 0.05 M asidi asidi: 1 mg/mL, zomveka, zopanda mtundu |
Kagwiritsidwe:
Calcitonin Salmon ndi mahomoni a polypeptide opangidwa ndi ultimobranchial gland ya salimoni.Ndiwochokera m'gulu la mapuloteni a calcitonin ndipo angagwiritsidwe ntchito pochiza matenda a Paget's of bone, postmenopausal osteoporosis (mafupa osalimba kapena opunduka), kapena kuchuluka kwa calcium m'magazi (hypercalcemia).Zikuwoneka kuti zili ndi zochita zofanana ndi ma calcitonins ochokera ku mammalian, koma mphamvu yake pa mg ndi yayikulu ndipo imakhala ndi nthawi yayitali yochitapo kanthu.Amagwira ntchito makamaka poletsa osteoclastic bone resorption, kuchepa kwa calcium mu seramu, komanso kukulitsa kutulutsa kwa phosphate, calcium, sodium magnesium ndi potaziyamu mu aimpso pochepetsa kuyamwa kwa tubular.
Mwa anthu, nsomba ya calcitonin imagwira ntchito kwambiri kuposa analogi yake yaumunthu.
Calcitonin (saumoni) imakhudzanso kukonzanso kwa mafupa ndi kachulukidwe ka mafupa chifukwa cholepheretsa ntchito ya osteoclast.Phindu la nsomba ya calcitonin pochiza osteoporotic fractures imakhalanso chifukwa cha kulimbikitsa gawo la cartilaginous la machiritso a fracture ndi kuchepetsa ululu.
Nsomba ya Calcitonin ikhoza kugwiritsidwa ntchito poyesa calcitonin receptor/cAMP poyesa kupezeka kwa calcitonin receptors zomwe zimawonetsedwa ndi maselo a TRAP +. salimoni calcitonin (sCT) pa chotchinga chapamimba mucosal mu makoswe omwe amakhala ndi kuzizira + kudziletsa kupsinjika (CRS).
