I-C-Telopeptide CAS;162929-64-8 L-Arginine L-α-glutamyl-L-lysyl-L-alanyl-L-histidyl-L-α-aspartylglycylglycyl-

I-C-terminal peptide (CTX), eyaziwa nangokuthi i-carboxy-terminal collagen crosslinking, iyi-peptide ye-C-terminal yama-collagens ane-fibrous njengohlobo I nohlobo II.Isetshenziswa njenge-biomarker ku-serum ukukala ukuguqulwa kwamathambo.Ingasetshenziselwa ukusiza odokotela banqume impendulo yesiguli ekwelashweni okungahlinzeki, kanye nokuhlola ingozi yesiguli yezinkinga ngesikhathi sokuphulukiswa ngemva kokungenelela kokuhlinzwa.[1] Ukuhlolwa kwezimpawu ze-CTX, okubizwa ngokuthi i-Serum CrossLaps, kucace kakhulu ukubuyisela amathambo kunanoma yikuphi okunye ukuhlola okutholakalayo njengamanje.

Ekuqaleni kwawo-2000, isixhumanisi siphawulwe phakathi kokusetshenziswa kwe-bisphosphonate kanye nokulimala komzimba emathanjeni.Ukuvinjelwa okukhulu komsebenzi we-osteoclast nge-bisphosphonate therapy kungabangela ukucindezelwa kokuguqulwa kwamathambo okujwayelekile, okuholela ekulimaleni kwesilonda ngemva kokulimala (njengokuhlinzwa kwamazinyo), ngisho nokuchayeka kwamathambo okungapholi ngokuzenzekelayo.Ngenxa yokuthi i-bisphosphonate ifakwe ngokukhethekile emathanjeni anenzuzo ephezulu, amazinga e-bisphosphonate emhlathini angase aphakanyiswe ngokukhethayo.

Ngokufika kokufakelwa kwamazinyo, inani elandayo leziguli zamazinyo zithola ukwelashwa okuhilela ukuphulukiswa kwamathambo emlonyeni, njengokufakwa kokuhlinzwa nokuxhunyelelwa amathambo.Ukuhlola ingozi ye-osteonecrosis ezigulini ezithatha ama-bisphosphonates, u-Rosen wethula i-CTX biomarker ku-2000.