C-Telopeptide CAS;162929-64-8 L-Arginine L-α-glutamyl-L-lysyl-L-alanyl-L-histidyl-L-a-aspartylglycylglycyl-

C-terminal peptide (CTX), oo sidoo kale loo yaqaan karboxy-terminal collagen crosslinking, waa peptide-ka C-terminal ee kolajiyeyaasha fayruuska ah sida nooca I iyo nooca II.Waxa loo isticmaalaa sidii biomarker ee serum si loo cabbiro wareegga lafaha.Waxaa loo isticmaali karaa in lagu caawiyo dhakhaatiirta inay go'aamiyaan jawaabta bukaan-socodka ee daaweynta aan qaliinka ahayn, iyo sidoo kale in la qiimeeyo khatarta bukaan-socodka ee dhibaatooyinka inta lagu jiro bogsashada ka dib faragelinta qalliinka.[1] Tijaabada calaamadaha CTX, ee loo yaqaan Serum CrossLaps, ayaa aad uga sii gaar ah soo noqoshada lafaha marka loo eego baaritaan kasta oo hadda jira.

Horraantii 2000-meeyadii, xiriir ayaa lagu xusay isticmaalka bisphosphonate iyo dhaawaca jireed ee lafaha.Joojinta xooggan ee shaqada osteoclast ee daaweynta bisphosphonate waxay keeni kartaa xakamaynta wareegga caadiga ah ee lafaha, taasoo keentay bogsashada dhaawaca dhaawaca ka dib (sida qalliinka ilkaha), iyo xitaa soo-gaadhista lafaha aan bogsanaynin.Sababtoo ah bisphosphonate waxay doorbidaysaa lafaha leh isbeddel sare, heerarka bisphosphonate ee daanka ayaa laga yaabaa in si xushmad leh loo kordhiyo.

Ilkaha oo soo baxay, tiro sii kordheysa ee bukaannada ilkuhu waxay ku socdaan daawaynta ku lug leh bogsashada lafaha ee afka, sida qalliinka qalliinka iyo tallaallada lafaha.Si loo qiimeeyo khatarta osteonecrosis ee bukaanada qaata bisphosphonates, Rosen wuxuu soo bandhigay biomarker CTX sanadkii 2000.