C-Telopeptide CAS;162929-64-8 L-Arginine L-α-glutamyl-L-lysyl-L-alanyl-L-histidyl-L-a-aspartylglycylglycyl-

C-terminal peptide (CTX), makwaara dị ka carboxy-terminal collagen crosslinking, bụ C-terminal peptide nke fibrous collagens dị ka ụdị I na ụdị II.A na-eji ya dị ka biomarker na serum iji tụọ ntụgharị ọkpụkpụ.Enwere ike iji ya nyere ndị dọkịta aka ikpebi nzaghachi onye ọrịa na ọgwụgwọ enweghị ịwa ahụ, yana iji chọpụta ihe ize ndụ onye ọrịa nwere n'oge ọgwụgwọ mgbe a wachara ya ahụ.[1] Nnwale maka ihe nrịbama CTX, nke a na-akpọ Serum CrossLaps, bụ nke a kapịrị ọnụ maka resorption ọkpụkpụ karịa ule ọ bụla ọzọ dị ugbu a.

Na mmalite 2000s, a hụrụ njikọ n'etiti ojiji bisphosphonate na mmebi physiological nke ọkpụkpụ.Mgbochi kpụ ọkụ n'ọnụ nke ọrụ osteoclast site na ọgwụgwọ bisphosphonate nwere ike ịkpata nkwụsị nke ntụgharị ọkpụkpụ nkịtị, na-ebute ọgwụgwọ ọnya na-adịghị mma mgbe trauma (dị ka ịwa ahụ eze), na ọbụna ọkpụkpụ na-adịghị agwọ ọrịa ozugbo.N'ihi na a na-edobe bisphosphonate ọkachamma n'ọkpụkpụ nwere nnukwu ntụgharị, ọkwa bisphosphonate dị na agba nwere ike ịhọrọ nke ọma.

Site na ọbịbịa nke ntinye eze, ọnụ ọgụgụ na-arịwanye elu nke ndị ọrịa eze na-enweta ọgwụgwọ gụnyere ọgwụgwọ ọkpụkpụ n'ọnụ, dị ka ntinye ịwa ahụ na ọkpụkpụ ọkpụkpụ.Iji chọpụta ihe ize ndụ nke osteonecrosis na ndị ọrịa na-ewere bisphosphonates, Rosen webatara CTX biomarker na 2000.