C-Telopeptide CAS;162929-64-8 L-Arginine L-α-glutamyl-L-lysyl-L-alanyl-L-histidyl-L-α-aspartylglycylglycyl-

I-C-terminal peptide (CTX), eyaziwa ngokuba yi-carboxy-terminal collagen crosslinking, yi-C-terminal peptide ye-fibrous collagens njengohlobo lwe-I kunye nohlobo lwe-II.Isetyenziswa njenge-biomarker kwi-serum ukulinganisa ukuguquka kwamathambo.Ingasetyenziselwa ukunceda oogqirha banqume impendulo yesigulane kunyango olungenalo utyando, kunye nokuvavanya ingozi yesigulane yeengxaki ngexesha lokuphilisa emva kokungenelela kokuhlinzwa.[1] Uvavanyo lwabamakishi be-CTX, ababizwa ngokuba yiSerum CrossLaps, luthe ngqo ngakumbi kwi-resorption yamathambo kunalo naluphi na uvavanyo olukhoyo ngoku.

Ekuqaleni kwe-2000, ikhonkco yaphawulwa phakathi kokusetyenziswa kwe-bisphosphonate kunye nomonakalo we-physiological to bone.Ukunyanzeliswa okukhulu komsebenzi we-osteoclast ngonyango lwe-bisphosphonate kunokubangela ukunyanzeliswa kokuguqulwa kwamathambo okuqhelekileyo, okubangelwa ukunyanzeliswa kwenxeba emva kokulimala (njengokuhlinzwa kwamazinyo), kunye nokuvezwa kwamathambo okungaphiliyo ngokuzenzekelayo.Ngenxa yokuba i-bisphosphonate ikhethwa ngokukhethekileyo emathanjeni ane-turnover ephezulu, amanqanaba e-bisphosphonate emhlathini anokukhethwa ngokunyuswa.

Ngokufika kokufakelwa kwamazinyo, inani elandayo lezigulane zamazinyo zifumana unyango olubandakanya ukuphiliswa kwamathambo emlonyeni, njengokufakelwa kotyando kunye nokufakelwa kwamathambo.Ukuvavanya umngcipheko we-osteonecrosis kwizigulane ezithatha i-bisphosphonates, uRosen wazisa i-CTX biomarker kwi-2000.