I-High Purity Pharmaceutical intermediate β-Nicotinamide Mononucleotide CAS:1094-61-7 Ukuthutha okuphephile ukuze kuqinisekiswe imvume yamasiko

Okuqukethwe komkhiqizo

Isebenzisa
I-β-Nicotinamide mononucleotide (NMN) isetshenziselwa ukutadisha ama-motifs abophayo ngaphakathi kwama-aptamers e-RNA kanye nezinqubo zokwenza kusebenze i-ribozyme ezibandakanya izingcezu ze-RNA ezicushiwe ze-β-nicotinamide mononucleotide (β-NMN).I-NMN iyinucleotide etholakala ku-ribose ne-nicotinamide.I-Niacinamide (i-nicotinamide,) iphuma kuvithamini B3, owaziwa nangokuthi i-niacin.) Njengesandulela samakhemikhali ezinto eziphilayo se-NAD+, ingase ibe usizo ekuvimbeleni i-pellagra.
I-β-Nicotinamide mononucleotide iyingxenye emaphakathi ku-biosynthesis ye-nicotinamide adenine dinucleotide (NAD+).I-Nicotinamide phosphoribosyltransferase (Nampt) igqugquzela ukujiya kwe-nicotinamide nge-5-phosphoribosyl-1-pyrophosphate ukuze ikhiqize i-β-NMN, kamuva eguqulelwa ku-NAD+ nge-β-NMN adenyltransferase. I-NAD biosynthesis kanye ne-glucose-stimulated secretion ye-insulin kumodeli yegundane ye-Nampt+/- yesifo se-metabolic, ebonisa indima ye-Namp ku-β cell function. Ngaphezu kwalokho, ku-500 mg/kg/ngosuku, kukhonjisiwe.

Okunye

I-Nicotinamide mononucleotide ("NMN" kanye" β- NMN ") iyi-nucleotide etholakala ku-ribose, i-Nicotinamide, i-Nicotinamide nucleoside ne-nicotinic acid. Kubantu, ama-enzyme amaningi asebenzisa i-NMN ukuze akhiqize i-Nicotinamide adenine dinucleotide (i-NADH i-Inposed). ukuthi i-NMN yafakwa emathunjini amancane phakathi nemizuzu engu-10 ngemva kokuphathwa komlomo futhi yaguqulwa yaba yi-Nicotinamide adenine dinucleotide (NAD +) nge-transporter ye-Slc12a8.

Ngenxa yokuthi i-NADH iyi-cofactor yezinqubo zangaphakathi ze-mitochondrial, ama-sirtuin, ne-PARP, i-NMN iye yacutshungulwa njenge-ejenti engase ibe yi-neuroprotective ne-anti-aging kumamodeli ezilwane.Lapho amazinga e-NAD+ enyuka, ukuvimbela ukubola kwe-mitochondrial kungahlehlisa ukuguga ezingeni lamaselula, kukwenze kudume kakhulu emikhiqizweni elwa nokuguga.Izinkampani zezithasiselo zokudla zikhuthaza ngenkuthalo imikhiqizo ye-NMN, zithi zinalezi zinzuzo.Kodwa-ke, kuze kube manje, akukabikho ucwaningo lwabantu lokufakazela kahle umphumela walo wokulwa nokuguga.Ucwaningo olwenziwa yi-Keio University lukhombisa ukuthi umthamo owodwa ofika ku-500 mg uphephile kwabesilisa.Ngo-2021, isilingo somtholampilo sathola ukuthi i-NMN yathuthukisa ukuzwela kwezicubu ze-insulin kwabesifazane abangaphambi kwesifo sikashukela, kuyilapho esinye isilingo somtholampilo sathola ukuthi ithuthukise umthamo we-aerobic wabagijimi abangafundi.

I-NMN ibhekana kalula nokuwohloka kwe-extracellular ngama-enzyme e-CD38, angavinjelwa yizinhlanganisela ezifana ne-CD38-IN-78c.