Abahuza ba farumasi nziza cyane β-Nicotinamide Mononucleotide CAS: 1094-61-7 Ubwikorezi bwiza kugirango ibicuruzwa bya gasutamo

Ibicuruzwa

Gukoresha
β-Nicotinamide mononucleotide (NMN) ikoreshwa mukwiga motif ihuza muri RNA aptamers hamwe na gahunda yo gukora ribozyme irimo β-nicotinamide mononucleotide (β-NMN) -bikora RNA ibice.NMN ni nucleotide ikomoka kuri ribose na nicotinamide.Niacinamide (nicotinamide,) ni inkomoko ya vitamine B3, izwi kandi ku izina rya niacin.) Nka biohimiki ibanziriza NAD +, irashobora kuba ingirakamaro mu gukumira pellagra.
β-Nicotinamide mononucleotide ni intera hagati ya biosynthesis ya nicotinamide adenine dinucleotide (NAD +).Nicotinamide fosiforiibosyltransferase (Nampt) itera ubukana bwa nicotinamide hamwe na 5-fosifori-1-pyrophosifate kugirango itange β-NMN, nyuma ihinduka NAD + na β-NMN adenyltransferase. Muri 50-100 μM, β-NMN yakoreshejwe mu kuzamura NAD biosynthesis na glucose-iterwa na insuline isohoka muri Nampt +/- imbeba yindwara ya metabolike, yerekana uruhare rwa Nampt mumikorere ya selile. Byongeye kandi, kuri 500 mg / kg / kumunsi, byerekanwe

Ibindi

Nikotinamide mononucleotide ("NMN" na "β- NMN") ni nucleotide ikomoka kuri ribose, Nicotinamide, Nicosinamide nucleoside na aside nikotinike. Mu bantu, imisemburo myinshi ikoresha NMN kugirango ikore Nicotinamide adenine dinucleotide (NADH). Mu mbeba, byasabwe. ko NMN yinjiye mu mara mato mu minota 10 nyuma yo gutegekwa mu kanwa hanyuma ihinduka Nikotinamide adenine dinucleotide (NAD +) ibinyujije mu bwikorezi bwa Slc12a8. Icyakora, iki kibazo cyakemuwe kandi ikibazo ntikirakemuka.

Bitewe na NADH kuba cofactor yimikorere yimbere ya mitochondial, sirtuins, na PARP, NMN yakozweho ubushakashatsi nkibishobora kuba neuroprotective na anti-gusaza mubyitegererezo byinyamaswa.Iyo urwego rwa NAD + rwiyongereye, kubuza kwangirika kwa mitochondial birashobora guhindura gusaza kurwego rwa selile, bigatuma bikundwa cyane mubicuruzwa birwanya gusaza.Ibigo byongera ibiryo byamamaza cyane ibicuruzwa bya NMN, bikavuga ko bifite inyungu.Ariko, kugeza ubu, nta bushakashatsi bwakozwe bwabantu bwerekana neza ingaruka zabwo zo kurwanya gusaza.Ubushakashatsi bwakozwe na kaminuza ya Keio bwerekana ko igipimo kimwe cya mg 500 gifite umutekano ku bagabo.Mu 2021, isuzuma ry’amavuriro ryerekanye ko NMN yazamuye imitsi ya insuline y’imitsi y’abagore babanje kurwara diyabete, mu gihe irindi suzuma ry’amavuriro ryagaragaje ko ryongereye ubushobozi bw’indege abiruka bikunda.

NMN irashobora kwangirika byoroshye na enzymes ya CD38, ishobora guhagarikwa nibintu nka CD38-IN-78c.