High Purity pharmaceutical intermediates β-Nicotinamide Mononucleotide CAS: 1094-61-7 Kev nyab xeeb kev thauj mus los kom paub meej txog kev lis kev cai

Cov ntsiab lus ntawm cov khoom

Siv
β-Nicotinamide mononucleotide (NMN) yog siv los kawm txog kev sib khi motifs hauv RNA aptamers thiab ribozyme activation txheej txheem uas muaj β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.NMN yog ib qho nucleotide muab tau los ntawm ribose thiab nicotinamide.Niacinamide (nicotinamide,) yog ib qho derivative ntawm vitamin B3, tseem hu ua niacin.) Raws li biochemical precursor ntawm NAD +, nws yuav pab tau rau kev tiv thaiv ntawm pellagra.
β-Nicotinamide mononucleotide yog ib qho nruab nrab hauv biosynthesis ntawm nicotinamide adenine dinucleotide (NAD +).Nicotinamide phosphoribosyltransferase (Nampt) catalyzes condensation ntawm nicotinamide nrog 5-phosphoribosyl-1-pyrophosphate los tsim β-NMN, uas yog tom qab hloov mus rau NAD + los ntawm β-NMN adenyltransferase.At 50 μM-1. NAD biosynthesis thiab glucose-stimulated insulin secretion hauv Nampt +/- nas qauv ntawm cov kab mob metabolic, qhia lub luag haujlwm rau Nampt hauv β cell muaj nuj nqi. Tsis tas li ntawd, ntawm 500 mg / kg / hnub, nws tau qhia.

Lwm yam

Nicotinamide mononucleotide ("NMN" thiab "β-NMN") yog nucleotide muab los ntawm ribose, Nicotinamide, Nicotinamide nucleoside thiab nicotinic acid. tias NMN tau nqus hauv cov hnyuv hauv 10 feeb tom qab kev tswj hwm qhov ncauj thiab hloov mus rau Nicotinamide adenine dinucleotide (NAD+) los ntawm Slc12a8 transporter Txawm li cas los xij, qhov kev soj ntsuam no tau nug thiab qhov teeb meem tseem tsis tau daws.

Vim NADH ua ib cofactor ntawm mitochondrial sab hauv cov txheej txheem, sirtuins, thiab PARP, NMN tau kawm raws li ib tug muaj peev xwm neuroprotective thiab anti-aging tus neeg sawv cev nyob rau hauv cov tsiaj qauv.Thaum NAD + qib nce, inhibiting mitochondrial lwj tuaj yeem thim rov qab kev laus ntawm qib cellular, ua rau nws nrov hauv cov khoom siv los tiv thaiv kev laus.Cov tuam txhab noj zaub mov txhawb nqa NMN cov khoom lag luam, thov kom muaj cov txiaj ntsig no.Txawm li cas los xij, txog tam sim no, tsis muaj tib neeg txoj kev tshawb fawb los ua pov thawj nws qhov kev tiv thaiv kev laus.Kev tshawb fawb los ntawm Keio University qhia tau hais tias ib koob tshuaj txog li 500 mg muaj kev nyab xeeb rau cov txiv neej.Hauv xyoo 2021, kev sim tshuaj xyuas pom tias NMN tau txhim kho cov leeg nqaij insulin rhiab heev ntawm cov poj niam ua ntej ntshav qab zib, thaum lwm qhov kev sim tshuaj pom tau tias nws txhim kho lub peev xwm aerobic ntawm cov neeg nyiam ua haujlwm.

NMN yog yooj yim raug rau extracellular degradation los ntawm CD38 enzymes, uas tuaj yeem inhibited los ntawm cov tebchaw xws li CD38-IN-78c.