Matsakaicin Matsakaicin Magungunan Magunguna β-Nicotinamide Mononucleotide CAS: 1094-61-7 Amintaccen sufuri don tabbatar da izinin kwastam

Abun cikin samfur

Amfani
Ana amfani da β-Nicotinamide mononucleotide (NMN) don nazarin abubuwan ɗaurewa a cikin RNA aptamers da hanyoyin kunna ribozyme da suka haɗa da β-nicotinamide mononucleotide (β-NMN) -abubuwan RNA da aka kunna.NMN wani nucleotide ne wanda aka samo daga ribose da nicotinamide.Niacinamide (nicotinamide,) wani nau'in bitamin B3 ne, wanda kuma aka sani da niacin.) A matsayin precursor na biochemical na NAD+, yana iya zama da amfani wajen rigakafin pellagra.
β-Nicotinamide mononucleotide shine matsakaici a cikin biosynthesis na nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) yana haɓaka haɓakar nicotinamide tare da 5-phosphoribosyl-1-pyrophosphate don samar da β-NMN, wanda daga baya ya canza zuwa NAD + ta β-NMN adenyltransferase.At 50-100 an yi amfani da β-NMN zuwa μM. NAD biosynthesis da glucose-stimulated insulin secretion a cikin samfurin Nampt +/- linzamin kwamfuta na cuta na rayuwa, yana nuna rawar Nampt a cikin aikin sel. Bugu da ƙari, a 500 mg / kg / day, an nuna shi.

Sauran

Nicotinamide mononucleotide ("NMN" da" β- NMN ") wani nucleotide ne wanda aka samo daga ribose, Nicotinamide, Nicotinamide nucleoside da nicotinic acid. A cikin mutane, yawancin enzymes suna amfani da NMN don samar da Nicotinamide adenine dinucleotide (NADH). cewa NMN ya shiga cikin ƙananan hanji a cikin mintuna 10 bayan gudanarwa ta baki kuma ya canza zuwa Nicotinamide adenine dinucleotide (NAD +) ta hanyar jigilar Slc12a8 Duk da haka, an tambayi wannan kallon kuma har yanzu ba a warware matsalar ba.

Saboda NADH kasancewa mai haɗin gwiwar matakai na ciki na mitochondrial, sirtuins, da PARP, an yi nazarin NMN a matsayin mai yuwuwar neuroprotective da wakili na rigakafin tsufa a cikin ƙirar dabba.Lokacin da matakan NAD + suka ƙaru, hana lalata mitochondrial na iya canza tsufa a matakin salula, yana sa ya shahara sosai a samfuran rigakafin tsufa.Kamfanonin kari na abinci suna haɓaka samfuran NMN, suna da'awar suna da waɗannan fa'idodin.Duk da haka, ya zuwa yanzu, babu wani binciken ɗan adam da ya tabbatar daidai da tasirinsa na rigakafin tsufa.Wani bincike da Jami'ar Keio ta yi ya nuna cewa kashi ɗaya na har zuwa 500 MG yana da lafiya ga maza.A cikin 2021, wani gwaji na asibiti ya gano cewa NMN ya inganta halayen insulin na tsoka na mata masu ciwon sukari, yayin da wani gwajin asibiti ya gano cewa ya inganta ƙarfin iska na masu gudu masu son.

NMN yana da sauƙin ƙaddamar da lalatawar salula ta CD38 enzymes, waɗanda za a iya hana su ta mahadi kamar CD38-IN-78c.