Dhexdhexaadinta dawooyinka daahirnimada sare leh β-Nicotinamide Mononucleotide CAS:1094-61-7 Gaadiid badbaado leh si loo hubiyo nadiifinta kastamka

Waxyaabaha ku jira badeecada

Adeegsada
β-Nicotinamide mononucleotide (NMN) waxaa loo isticmaalaa in lagu barto motifs ku xiran gudaha RNA aptamers iyo hababka firfircoonida ribozyme ee ku lug leh β-nicotinamide mononucleotide (β-NMN) - jajabyada RNA firfircoon.NMN waa nucleotide ka soo jeeda ribose iyo nicotinamide.Niacinamide (nicotinamide,) waa nooc ka mid ah fitamiin B3, oo sidoo kale loo yaqaan niacin.) Sida horudhac biochemical ee NAD+, waxaa laga yaabaa inay faa'iido u leedahay ka hortagga pellagra.
β-Nicotinamide mononucleotide waa dhex dhexaad u ah biosynthesis ee nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) waxay kicisaa uumida nicotinamide oo leh 5-phosphoribosyl-1-pyrophosphate si ay u abuurto β-NMN, taas oo ka dib loo beddelay NAD + by β-NMN adenyltransferase.At 50,NM ayaa loo isticmaalay NM NAD biosynthesis iyo dheecaanka insulin-kicinta gulukooska ee Nampt +/- qaabka jiirka ee cudurka dheef-shiid kiimikaadka, oo muujinaya doorka Nampt ee shaqada unugyada β. Intaa waxaa dheer, 500 mg / kg / maalin, ayaa la muujiyay.

Mid kale

Nikotinamide mononucleotide ("NMN" iyo" β- NMN ") waa nucleotide ka soo jeeda ribose, Nicotinamide, Nicotinamide nucleoside iyo nicotinic acid. Bini'aadamka, enzymes badan ayaa isticmaala NMN si ay u soo saaraan Nicotinamide adenine dinucleotide (NADH) ee jiirarka, waxaa la soo jeediyay. in NMN lagu nuugo mindhicirka yar 10 daqiiqo gudahood ka dib maamulka afka oo loo beddelay Nicotinamide adenine dinucleotide (NAD+) iyada oo loo marayo gaadiidka Slc12a8 Si kastaba ha ahaatee, indha-indheyntan ayaa la weydiiyay oo arrintu weli waa mid aan la xallin.

Sababtoo ah NADH oo ah cofactor ee hababka gudaha ee mitochondrial, sirtuins, iyo PARP, NMN waxaa loo bartay sidii wakiilka neuroprotective iyo ka hortagga gabowga ee moodooyinka xayawaanka.Marka heerarka NAD + ay kordhaan, joojinta suuska mitochondrial waxay ka noqon kartaa gabowga heerka gacanta, taasoo ka dhigaysa mid caan ku ah alaabada ka hortagga gabowga.Shirkadaha kabka cuntada waxay si firfircoon kor ugu qaadaan alaabta NMN, iyagoo sheeganaya inay leeyihiin faa'iidooyinkan.Si kastaba ha ahaatee, ilaa hadda, ma jirto daraasad bani'aadam ah oo si sax ah u caddaynaysa saameynteeda gabowga.Daraasad ay samaysay jaamacadda Keio ayaa muujisay in hal dose oo ah ilaa 500 mg ay ammaan u tahay ragga.Sannadkii 2021, tijaabo caafimaad ayaa lagu ogaaday in NMN ay hagaajisay dareenka insulinta muruqa ee haweenka ka hor cudurka macaanka, halka tijaabo kale oo caafimaad lagu ogaaday inay wanaajisay awoodda aerobic ee orodyahannada hiwaayadda ah.

NMN waxaa si fudud loogu sakhiray hoos u dhigista unugyada ka baxsan unugyada CD38 enzymes, kuwaas oo lagu joojin karo xeryahooda sida CD38-IN-78c.