Bohloeki bo phahameng ba meriana β-Nicotinamide Mononucleotide CAS: 1094-61-7 Lipalangoang tse sireletsehileng ho netefatsa hore ho na le tumello ea meetlo.

Likahare tsa sehlahisoa

Lisebelisoa
β-Nicotinamide mononucleotide (NMN) e sebelisetsoa ho ithuta li-motifs tse tlamang ka har'a li-aptamers tsa RNA le mekhoa ea ts'ebetso ea ribozyme e kenyelletsang likaroloana tsa RNA tse entsoeng ke β-nicotinamide mononucleotide (β-NMN).NMN ke nucleotide e nkiloeng ho ribose le nicotinamide.Niacinamide (nicotinamide,) e nkiloeng ho vithamine B3, eo hape e tsejoang e le niacin.) Joaloka selelekela sa biochemical sa NAD+, e ka ba molemo ho thibela pellagra.
β-Nicotinamide mononucleotide ke karolo e bohareng ea biosynthesis ea nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) e etsa hore ho be le condensation ea nicotinamide ka 5-phosphoribosyl-1-pyrophosphate ho hlahisa β-NMN, eo hamorao e fetoloang ho NAD+ ka β-NMN adenyltransferase.At 50-MNNβ e sebelisitsoe NAD biosynthesis le glucose-stimulated insulin secretion ka Nampt +/- mouse model ea lefu la metabolism, e bontšang karolo ea Nampt ka β cell function. Ho feta moo, ho 500 mg / kg / letsatsi, ho bontšitsoe

Tse ding

Nicotinamide mononucleotide ("NMN" le" β- NMN ") ke nucleotide e nkiloeng ho ribose, Nicotinamide, Nicotinamide nucleoside le nicotinic acid. Ho batho, li-enzyme tse ngata li sebelisa NMN ho hlahisa Nicotinamide adenine dinucleotice, NADH e ile ea hlahisoa. hore NMN e ile ea kenngoa ka maleng a manyenyane ka hare ho metsotso ea 10 ka mor'a tsamaiso ea molomo 'me ea fetoloa Nicotinamide adenine dinucleotide (NAD +) ka sekepe sa Slc12a8.

Ka lebaka la hore NADH ke motsoako oa mekhoa ea ka hare ea mitochondrial, li-sirtuins, le PARP, NMN e ithutiloe e le ntho e ka 'nang ea e-ba moemeli oa methapo ea kutlo le e khahlanong le botsofali mefuteng ea liphoofolo.Ha maemo a NAD + a eketseha, ho thibela ho bola ha mitochondrial ho ka khutlisa botsofali boemong ba lisele tsa cellular, ho etsa hore e tumme haholo lihlahisoa tse thibelang botsofali.Lik'hamphani tse tlatsetsang lijong li khothalletsa lihlahisoa tsa NMN ka mafolofolo, li bolela hore li na le melemo ena.Leha ho le joalo, ho fihlela joale, ha ho so be le boithuto ba motho ho paka ka nepo phello ea eona e khahlanong le botsofali.Phuputso e entsoeng ke Univesithi ea Keio e bontša hore tekanyo e le 'ngoe ea ho fihla ho 500 mg e bolokehile ho banna.Ka 2021, teko ea bongaka e fumane hore NMN e ntlafalitse kutloisiso ea mesifa ea insulin ho basali ba prediabetes, ha teko e 'ngoe ea bongaka e fumane hore e ntlafalitse bokhoni ba aerobic ba limathi tse sa sebetseng.

NMN e kenngoa habonolo ho senyeha ha extracellular ke li-enzyme tsa CD38, tse ka thibeloang ke metsoako e kang CD38-IN-78c.