Nā kikowaena lāʻau maʻemaʻe maʻemaʻe kiʻekiʻe β-Nicotinamide Mononucleotide CAS:1094-61-7 ʻO ka halihali palekana e hōʻoia i ka ʻae ʻana i nā dute.

ʻIke huahana

Hoʻohana
Hoʻohana ʻia ka β-Nicotinamide mononucleotide (NMN) e aʻo i nā kumu paʻa i loko o nā aptamers RNA a me nā kaʻina hana hoʻoulu ribozyme e pili ana i nā ʻāpana RNA β-nicotinamide mononucleotide (β-NMN).ʻO NMN kahi nucleotide i loaʻa mai ka ribose a me ka nicotinamide.ʻO ka Niacinamide (nicotinamide,) he mea ia o ka huaʻa B3, ʻike ʻia hoʻi ʻo niacin.) Ma ke ʻano he biochemical precursor o NAD +, pono paha ia i ka pale ʻana i ka pellagra.
ʻO ka β-Nicotinamide mononucleotide kahi mea waena i ka biosynthesis o nicotinamide adenine dinucleotide (NAD+).Hoʻopili ʻo Nicotinamide phosphoribosyltransferase (Nampt) i ka condensation o nicotinamide me 5-phosphoribosyl-1-pyrophosphate e hoʻohua i ka β-NMN, a laila hoʻololi ʻia i NAD + e β-NMN adenyltransferase. Ma 50-100 μM, ua hoʻohana ʻia ka β-NMN. NAD biosynthesis a me ka glucose-stimulated insulin secretion in a Nampt +/- mouse model of metabolic disease, e hōʻike ana i kahi kuleana no Nampt i ka hana β cell. Eia kekahi, ma 500 mg / kg / lā, ua hōʻike ʻia.

'ē aʻe

ʻO Nicotinamide mononucleotide ("NMN" a me" β- NMN ") he nucleotide i loaʻa mai ribose, Nicotinamide, Nicotinamide nucleoside a me nicotinic acid. I loko o nā kānaka, nui nā enzymes e hoʻohana i ka NMN e hana i ka Nicotinamide adenine dinucleotide (NADH). I nāʻiole, ua manaʻoʻia. ua komo ʻia ka NMN i loko o ka ʻōpū liʻiliʻi i loko o 10 mau minuke ma hope o ka lawelawe waha a hoʻololi ʻia i Nicotinamide adenine dinucleotide (NAD+) ma o ka transporter Slc12a8 Eia naʻe, ua nīnau ʻia kēia ʻike a ʻaʻole i hoʻoholo ʻia.

Ma muli o ka NADH he cofactor o nā kaʻina hana kūloko mitochondrial, sirtuins, a me PARP, ua aʻo ʻia ʻo NMN ma ke ʻano he neuroprotective a me ka anti-aging agent i nā ʻano holoholona.Ke piʻi aʻe nā pae NAD +, hiki i ka pale ʻana i ka mitochondrial decay ke hoʻohuli i ka ʻelemakule ma ka pae cellular, e kaulana nui ai i nā huahana anti-aging.Hoʻolaha ikaika nā ʻoihana meaʻai meaʻai i nā huahana NMN, me ka ʻōlelo ʻana i loaʻa kēia mau pono.Eia naʻe, i kēia manawa, ʻaʻohe aʻo kanaka e hōʻoia pololei i kona hopena anti-kahiko.Ua hōʻike ʻia kahi haʻawina e ke Kulanui ʻo Keio he palekana hoʻokahi a hiki i ka 500 mg no nā kāne.I ka makahiki 2021, ua ʻike ʻia kahi hoʻokolohua lapaʻau ua hoʻomaikaʻi ʻo NMN i ka naʻau o ka insulin muscle o nā wahine ma mua o ka maʻi diabetes, aʻo kahi hoʻokolohua lapaʻau ʻē aʻe i ʻike ʻia ua hoʻomaikaʻi ia i ka mana aerobic o nā poʻe holo amateur.

Hoʻokomo maʻalahi ka NMN i ka hoʻohaʻahaʻa extracellular e nā enzymes CD38, hiki ke kāohi ʻia e nā pūhui e like me CD38-IN-78c.