Ndị na-ahụ maka ọgwụ dị elu β-Nicotinamide Mononucleotide CAS: 1094-61-7 Ụgbọ njem dị mma iji hụ na mkpochapụ kọstọm

Ọdịnaya ngwaahịa

Na-eji
A na-eji β-Nicotinamide mononucleotide (NMN) na-amụ ihe ejikọtara n'ime RNA aptamers na usoro ntinye ribozyme gụnyere β-nicotinamide mononucleotide (β-NMN) -arụ ọrụ RNA iberibe.NMN bụ nucleotide sitere na ribose na nicotinamide.Niacinamide (nicotinamide,) bụ ihe sitere na vitamin B3, nke a makwaara dị ka niacin.) Dị ka biochemical precursor nke NAD +, ọ nwere ike ịba uru na mgbochi nke pellagra.
β-Nicotinamide mononucleotide bụ etiti na biosynthesis nke nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) na-eme ka condensation nke nicotinamide na 5-phosphoribosyl-1-pyrophosphate na-emepụta β-NMN, bụ nke emesị gbanwee gaa na NAD + site na β-NMN adenyltransferase.At 50-100 β-M jiri ya μM. NAD biosynthesis na insulin na-akpali akpali nke insulin n'ụdị Nampt +/- òké nke ọrịa metabolic, na-egosipụta ọrụ maka Nampt na ọrụ β cell. Ọzọkwa, na 500 mg / kg / ụbọchị, egosila ya.

Ndị ọzọ

Nicotinamide mononucleotide ("NMN" na" β- NMN ") bụ nucleotide sitere na ribose, Nicotinamide, Nicotinamide nucleoside na nicotinic acid. N'ime ụmụ mmadụ, ọtụtụ enzymes na-eji NMN mepụta Nicotinamide adenine dinucleotide (NADH). na NMN etinyere n'ime obere eriri afọ n'ime nkeji 10 mgbe nchịkwa ọnụ gasịrị wee ghọọ Nicotinamide adenine dinucleotide (NAD +) site na onye na-ebugharị Slc12a8, Otú ọ dị, a jụrụ ajụjụ a nleba anya na okwu ahụ ka edozibeghị.

N'ihi NADH ịbụ onye na-akwado usoro nke ime mitochondrial, sirtuins, na PARP, a mụọla NMN dị ka onye na-ahụ maka neuroprotective na mgbochi ịka nká n'ụdị anụmanụ.Mgbe ọkwa NAD + na-abawanye, igbochi mmebi mitochondrial nwere ike gbanwee ịka nká na ọkwa cellular, na-eme ka ọ bụrụ ihe ewu ewu na ngwaahịa mgbochi ịka nká.Companieslọ ọrụ mgbakwunye nri na-arụsi ọrụ ike na-akwalite ngwaahịa NMN, na-ekwu na ha nwere uru ndị a.Agbanyeghị, ka ọ dị ugbu a, enwebeghị ọmụmụ mmadụ iji gosipụta n'ụzọ ziri ezi mmetụta mgbochi ịka nká.Nnyocha nke Mahadum Keio na-egosi na otu dose nke ruru 500 mg dị mma maka ụmụ nwoke.Na 2021, nnwale ụlọ ọgwụ chọpụtara na NMN kwalitere mmetụta insulin nke anụ ahụ nke ụmụ nwanyị buru ibu, ebe nnwale ụlọ ọgwụ ọzọ chọpụtara na ọ kwalitere ikike ikuku nke ndị na-agba ọsọ amateur.

NMN na-adị mfe n'okpuru mmebi nke extracellular site na CD38 enzymes, nke enwere ike igbochi ya site na ogige ndị dị ka CD38-IN-78c.